Extended treatment duration for hepatitis C virus type 1: comparing 48 versus 72 weeks of peginterferon-alfa-2a plus ribavirin.

Author: AlshuthUlrich, BergThomas, BuggischPeter, GerlachTilman, GoeserTobias, HeintgesTobias, KallinowskiBirgit, KlinkerHartwig, MartusPeter, NasserSamer, PapeGerd R, RasenackJens, SarrazinChristoph, SchmidtWolfgang E, SpenglerUlrich, ZeuzemStefan, von WagnerMichael

Paper Details 
Original Abstract of the Article :
BACKGROUND & AIMS: The treatment of patients infected with hepatitis C virus (HCV) type 1 remains a challenge necessitating innovative strategies to improve treatment outcome. The extension of treatment duration beyond 48 weeks is one possible strategy to address this problem. METHODS: The efficacy...See full text at original site
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引用元:
https://doi.org/10.1053/j.gastro.2006.02.015

データ提供:米国国立医学図書館(NLM)

Extending Treatment Duration for Hepatitis C: A Comparative Study

Hepatitis C virus (HCV) infection is a significant global health concern, and treatment options have evolved over time. This study investigates the efficacy and safety of extending treatment duration beyond 48 weeks for patients with HCV type 1 infection. The authors compared the outcomes of 48 weeks versus 72 weeks of treatment with peginterferon-alfa-2a plus ribavirin, analyzing sustained virologic response (SVR) rates and adverse events. Their findings provide valuable insights into the potential benefits of extended treatment duration for certain patients.

Extended Treatment Duration: A Potential Benefit for Slow Responders

The study found that extended treatment duration (72 weeks) did not significantly improve overall SVR rates compared to standard treatment (48 weeks). However, the authors observed a significant benefit for patients who showed a slow virologic response, defined as HCV-RNA positive at week 12 but negative at week 24. These patients achieved significantly higher SVR rates with extended treatment duration. This suggests that extended treatment may be a valuable option for selected patients with slow virologic response, potentially improving their chances of achieving a sustained viral cure.

Tailoring Treatment Strategies for Hepatitis C: A Personalized Approach

This study emphasizes the importance of tailoring treatment strategies for patients with HCV infection. The authors' findings suggest that extended treatment duration may be beneficial for a subset of patients with slow virologic response. This personalized approach to treatment allows for the selection of the most effective therapeutic strategy for individual patients, maximizing the likelihood of achieving a sustained viral cure.

Dr.Camel's Conclusion

The treatment of Hepatitis C, like a desert trek, can be challenging and unpredictable. This study helps us to navigate the path towards a cure, highlighting the potential benefits of extended treatment duration for certain patients. By customizing treatment strategies to individual patient needs, we can improve outcomes and enhance the chances of achieving a sustained viral cure for those affected by this debilitating disease.

Date :
  1. Date Completed 2006-05-15
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16618403

DOI: Digital Object Identifier

10.1053/j.gastro.2006.02.015

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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