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The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine.

Author: HuangJin-Ding, LaiMing-Liang, LuWen-Jen

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the effect of ergoloid mesylates and ginkgo biloba on ticlopidine pharmacokinetics. Ergoloid mesylates, but not ginkgo biloba, significantly decreased the AUC and C(max) of ticlopidine.
Paper Details　
Original Abstract of the Article :
Ticlopidine is sometimes coadministered with ergoloid mesylates or ginkgo biloba in clinical situations. Our objective was to examine the effect of ergoloid mesylates and ginkgo biloba on ticlopidine pharmacokinetics. Ticlopidine, ergoloid mesylates, and ginkgo biloba significantly inhibited the org...See full text at original site
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引用元：
https://doi.org/10.1177/0091270006287024

データ提供：米国国立医学図書館（NLM）

Drug Interactions: Navigating the Desert of Pharmacokinetics

Drug interactions can be like shifting sands, altering the effectiveness and safety of medications. This study investigates the potential interaction between ticlopidine, an antiplatelet drug, and ergoloid mesylates or ginkgo biloba, commonly used for cognitive impairment. The authors found that ergoloid mesylates significantly reduced the bioavailability of ticlopidine, likely by inhibiting its intestinal absorption. This finding underscores the importance of considering potential interactions when co-administering medications.

Navigating Drug Interactions in the Desert of Pharmacokinetics

This study highlights the complexity of drug interactions and the importance of understanding their potential impact. The authors' findings suggest that co-administration of ergoloid mesylates with ticlopidine may lead to reduced drug efficacy. This underscores the need for careful monitoring and personalized adjustments in medication regimens.

Navigating the Desert of Drug Interactions

Drug interactions can be a complex and unpredictable phenomenon, like navigating a shifting desert landscape. This study underscores the importance of consulting with a healthcare professional to discuss potential interactions and ensure the safe and effective use of medications. By staying informed and seeking professional guidance, we can navigate the complexities of drug interactions and optimize our medication regimens.

Dr. Camel's Conclusion

This study reminds us that the desert of pharmacokinetics can be filled with hidden dangers, such as drug interactions. Understanding the potential impact of co-administered medications is crucial for navigating this landscape and ensuring the safety and efficacy of our treatments. As we continue to explore the vast desert of drug interactions, it's essential to maintain a vigilant approach, seeking guidance from healthcare professionals to ensure optimal health outcomes.

Date :
  1. Date Completed 2006-11-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16707409

DOI: Digital Object Identifier

10.1177/0091270006287024

SNS
PICO Info
in preparation
Languages

English

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