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Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial.

Author: FeigerAlan D, RickelsKarl, RobinsonDonald S, RynnMoira A, ZimbroffDan L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the efficacy, safety, and tolerability of the selegiline transdermal system (STS) for treating major depressive disorder (MDD). The results showed that STS was significantly more effective than placebo in improving depression symptoms, with a modest treatment effect primarily due to insomnia side effects. The study concluded that STS has an improved margin of safety compared with oral monoamine oxidase inhibitors and represents a useful addition to the existing array of antidepressants.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: This study investigated the efficacy, safety, and tolerability of the selegiline transdermal system (STS) administered in a dose range of 6 mg/24 hours to 12 mg/24 hours for treating major depressive disorder (MDD). METHOD: Patients meeting DSM-IV criteria for MDD (N = 265) were randomly...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v67n0905

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2006-11-06
  2. Date Revised 2019-09-02
Further Info :

Pubmed ID

17017821

DOI: Digital Object Identifier

10.4088/jcp.v67n0905

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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