Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial.

Author: AllaartCornelia F, BreedveldFerdinand C, DijkmansBen A C, EwalsJacques A P M, Goekoop-RuitermanYvonne P M, HazesJ Mieke W, KerstensPit J S M, MalléeConstant, PeetersAndré J, ZwindermanAelko H, de BeusWim M, de Jonge-BokJohanna M, de SonnavillePeter B J, de Vries-BouwstraJeska K, van ZebenDerkjen

Paper Details 
Original Abstract of the Article :
BACKGROUND: In patients with early rheumatoid arthritis, initial combination therapies provide earlier clinical improvement and less progression of joint damage after 1 year compared with initial monotherapies (as demonstrated in the BeSt study). OBJECTIVE: To evaluate whether the initial clinical ...See full text at original site
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引用元:
https://doi.org/10.7326/0003-4819-146-6-200703200-00005

データ提供:米国国立医学図書館(NLM)

Treating Early Rheumatoid Arthritis: A Journey Through the Desert of Inflammation

Rheumatoid arthritis (RA), a chronic autoimmune disorder, causes inflammation and pain in the joints, leading to significant disability. This study, published in the field of Rheumatology, compares various treatment strategies for early RA, seeking to optimize therapeutic outcomes and minimize disease progression. The researchers explored the efficacy of different treatment approaches, including sequential monotherapy, step-up combination therapy, and initial combination therapy with either high-dose prednisone or infliximab.

Combination Therapies: A Refreshing Oasis in the Desert of RA

The study found that initial combination therapies, including those with high-dose prednisone or infliximab, led to faster clinical improvements and reduced joint damage compared to monotherapy approaches. While all treatment strategies eventually showed similar clinical improvements over time, initial combination therapies offered a more effective starting point for managing early RA.

Managing RA: A Guide Through the Desert of Inflammation

This research provides valuable insights into the management of early RA, highlighting the potential benefits of initial combination therapies for achieving better outcomes. It emphasizes the importance of early intervention and individualized treatment strategies for managing this challenging disease.

Dr.Camel's Conclusion

This research underscores the importance of early intervention and tailored treatment strategies for managing early rheumatoid arthritis. It highlights the potential benefits of initial combination therapies for achieving better outcomes, particularly in minimizing joint damage and promoting long-term disease control.

Date :
  1. Date Completed 2007-04-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

17371885

DOI: Digital Object Identifier

10.7326/0003-4819-146-6-200703200-00005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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