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Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial.
Author: AllaartCornelia F, BreedveldFerdinand C, DijkmansBen A C, EwalsJacques A P M, Goekoop-RuitermanYvonne P M, HazesJ Mieke W, KerstensPit J S M, MalléeConstant, PeetersAndré J, ZwindermanAelko H, de BeusWim M, de Jonge-BokJohanna M, de SonnavillePeter B J, de Vries-BouwstraJeska K, van ZebenDerkjen
Original Abstract of the Article :
BACKGROUND: In patients with early rheumatoid arthritis, initial combination therapies provide earlier clinical improvement and less progression of joint damage after 1 year compared with initial monotherapies (as demonstrated in the BeSt study). OBJECTIVE: To evaluate whether the initial clinical ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.7326/0003-4819-146-6-200703200-00005
データ提供:米国国立医学図書館(NLM)
Treating Early Rheumatoid Arthritis: A Journey Through the Desert of Inflammation
Rheumatoid arthritis (RA), a chronic autoimmune disorder, causes inflammation and pain in the joints, leading to significant disability. This study, published in the field of Rheumatology, compares various treatment strategies for early RA, seeking to optimize therapeutic outcomes and minimize disease progression. The researchers explored the efficacy of different treatment approaches, including sequential monotherapy, step-up combination therapy, and initial combination therapy with either high-dose prednisone or infliximab.
Combination Therapies: A Refreshing Oasis in the Desert of RA
The study found that initial combination therapies, including those with high-dose prednisone or infliximab, led to faster clinical improvements and reduced joint damage compared to monotherapy approaches. While all treatment strategies eventually showed similar clinical improvements over time, initial combination therapies offered a more effective starting point for managing early RA.
Managing RA: A Guide Through the Desert of Inflammation
This research provides valuable insights into the management of early RA, highlighting the potential benefits of initial combination therapies for achieving better outcomes. It emphasizes the importance of early intervention and individualized treatment strategies for managing this challenging disease.
Dr.Camel's Conclusion
This research underscores the importance of early intervention and tailored treatment strategies for managing early rheumatoid arthritis. It highlights the potential benefits of initial combination therapies for achieving better outcomes, particularly in minimizing joint damage and promoting long-term disease control.
Date :
- Date Completed 2007-04-02
- Date Revised 2022-04-08
Further Info :
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