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The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder.

Author: CoghillDavid R, MatthewsKeith, RhodesSinead M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of chronic methylphenidate (MPH) administration on neuropsychological functioning in children with attention-deficit/hyperactivity disorder (ADHD). The study aimed to clarify the inconsistent findings regarding the neuropsychological effects of MPH and their relationship to clinical efficacy.
Paper Details　
Original Abstract of the Article :
The reported neuropsychological effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopsych.2006.12.030

データ提供：米国国立医学図書館（NLM）

Methylphenidate: A Desert of Inconsistent Effects

Methylphenidate (MPH) is a common medication for treating Attention-Deficit/Hyperactivity Disorder (ADHD). It's like a camel caravan crossing a vast, restless desert - ADHD can be difficult to manage. However, the effects of MPH on neuropsychological functioning are not always clear. This study investigated the long-term effects of MPH on drug-naive boys with ADHD.

Navigating the Desert of Neuropsychological Effects

The researchers found that while MPH improved attention and reduced hyperactivity, it also had some unexpected effects. They observed changes in cognitive flexibility and planning abilities. Think of it as the caravan encountering shifting sand dunes – the brain may need to adapt to the medication. The study highlights the importance of considering the potential neuropsychological effects of long-term MPH treatment.

Navigating the Desert: A Need for Careful Monitoring

This study emphasizes the need for careful monitoring of patients taking MPH. It's important to weigh the benefits against the potential risks and to adjust treatment accordingly. Like a caravan leader guiding their team, healthcare providers must be vigilant in their approach to medication management.

Dr.Camel's Conclusion

While MPH can be helpful for managing ADHD, the study shows that long-term use may have unexpected neuropsychological effects. It's like navigating a desert - the terrain can be unpredictable, and we need to be prepared for challenges along the way.

Date :
  1. Date Completed 2008-01-09
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

17543895

DOI: Digital Object Identifier

10.1016/j.biopsych.2006.12.030

SNS
PICO Info
in preparation
Languages

English

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