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Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.
Author: CavalheiroEsper Abräo, Naffah-MazzacorattiMaria da Graça, PeresMario Fernando Prieto, Senne SoaresCarlos Augusto, VieiraDomingos Sávio deSouza, ZukermanEliova
Original Abstract of the Article :
Chronic migraine (CM) is a common disorder, affecting 2% to 3% of the general population. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, central sensitization, and may be linked to migraine chronification. Triptans brought a novel option for the acute migrain...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.1526-4610.2007.00812.x
データ提供:米国国立医学図書館(NLM)
Chronic Migraine: Unraveling the Mystery in the Desert of Pain
Chronic migraine is a debilitating condition, a constant desert of pain that affects millions of people worldwide. This study explores the role of glutamate, a neurotransmitter crucial for brain function, in the development and treatment of chronic migraine. The researchers investigated the relationship between glutamate levels in cerebrospinal fluid (CSF) and the overuse of triptans, a class of medications commonly used to treat migraine headaches.
The study, like a journey across a vast and treacherous desert, revealed a potential link between glutamate levels in CSF and the overuse of triptans. The researchers hypothesized that glutamate might be involved in central sensitization, a phenomenon that can contribute to the chronification of migraine. This research, like a flickering candle in the darkness, offers a new avenue for understanding the complexities of chronic migraine.
A New Path to Understanding: Navigating the Desert of Pain
The study's findings, like a map leading through a dense desert, offer a new perspective on the potential role of glutamate in chronic migraine. The researchers have identified a possible link between glutamate levels and triptan overuse, suggesting that further investigation into the role of this neurotransmitter may lead to new treatment strategies.
Living with Migraine: Finding a Oasis in the Desert of Pain
As Dr. Camel, I have personally witnessed the impact of chronic migraine, a condition that can severely impact daily life. This research offers hope for a better understanding of the underlying mechanisms of this debilitating condition. By delving deeper into the role of glutamate, we may one day find a way to alleviate the constant pain and suffering that migraine patients endure.
Dr. Camel's Conclusion
Chronic migraine, like a relentless sandstorm, can wreak havoc on the lives of those affected. This study, like a flickering candle in the darkness, sheds light on the potential role of glutamate in the development and treatment of this debilitating condition. The research suggests that further investigation into the role of glutamate in central sensitization may lead to new treatment strategies, offering a path towards a brighter future for migraine sufferers.
Date :
- Date Completed 2007-08-01
- Date Revised 2016-11-24
Further Info :
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