Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.

Author: CavalheiroEsper Abräo, Naffah-MazzacorattiMaria da Graça, PeresMario Fernando Prieto, Senne SoaresCarlos Augusto, VieiraDomingos Sávio deSouza, ZukermanEliova

Paper Details 
Original Abstract of the Article :
Chronic migraine (CM) is a common disorder, affecting 2% to 3% of the general population. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, central sensitization, and may be linked to migraine chronification. Triptans brought a novel option for the acute migrain...See full text at original site
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引用元:
https://doi.org/10.1111/j.1526-4610.2007.00812.x

データ提供:米国国立医学図書館(NLM)

Chronic Migraine: Unraveling the Mystery in the Desert of Pain

Chronic migraine is a debilitating condition, a constant desert of pain that affects millions of people worldwide. This study explores the role of glutamate, a neurotransmitter crucial for brain function, in the development and treatment of chronic migraine. The researchers investigated the relationship between glutamate levels in cerebrospinal fluid (CSF) and the overuse of triptans, a class of medications commonly used to treat migraine headaches.

The study, like a journey across a vast and treacherous desert, revealed a potential link between glutamate levels in CSF and the overuse of triptans. The researchers hypothesized that glutamate might be involved in central sensitization, a phenomenon that can contribute to the chronification of migraine. This research, like a flickering candle in the darkness, offers a new avenue for understanding the complexities of chronic migraine.

A New Path to Understanding: Navigating the Desert of Pain

The study's findings, like a map leading through a dense desert, offer a new perspective on the potential role of glutamate in chronic migraine. The researchers have identified a possible link between glutamate levels and triptan overuse, suggesting that further investigation into the role of this neurotransmitter may lead to new treatment strategies.

Living with Migraine: Finding a Oasis in the Desert of Pain

As Dr. Camel, I have personally witnessed the impact of chronic migraine, a condition that can severely impact daily life. This research offers hope for a better understanding of the underlying mechanisms of this debilitating condition. By delving deeper into the role of glutamate, we may one day find a way to alleviate the constant pain and suffering that migraine patients endure.

Dr. Camel's Conclusion

Chronic migraine, like a relentless sandstorm, can wreak havoc on the lives of those affected. This study, like a flickering candle in the darkness, sheds light on the potential role of glutamate in the development and treatment of this debilitating condition. The research suggests that further investigation into the role of glutamate in central sensitization may lead to new treatment strategies, offering a path towards a brighter future for migraine sufferers.

Date :
  1. Date Completed 2007-08-01
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

17578532

DOI: Digital Object Identifier

10.1111/j.1526-4610.2007.00812.x

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SNS
PICO Info
in preparation
Languages

English

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