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Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis.

Author: BergerChristoph, BischoffGian, BuechnerKatja, GervaixAlain, GirardinEric, GoetschelPhilippe, HunzikerUrs, HusarikDaniela, MolinariLuciano, NadalDavid, NeuhausThomas J, ParvexPaloma, RudinChristoph, StockerSergio, WilliUlrich

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral ceftibuten for 14 days was as effective as intravenous ceftriaxone followed by oral ceftibuten in children with acute pyelonephritis and scintigraphy-documented lesions. The oral therapy allowed for outpatient management in the majority of cases.
Paper Details　
Original Abstract of the Article :
The hypothesis was tested that oral antibiotic treatment in children with acute pyelonephritis and scintigraphy-documented lesions is equally as efficacious as sequential intravenous/oral therapy with respect to the incidence of renal scarring. A randomised multi-centre trial was conducted in 365 ch...See full text at original site
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引用元：
https://doi.org/10.1007/s00431-007-0638-1

データ提供：米国国立医学図書館（NLM）

Oral vs Intravenous/Oral Cephalosporins for Pyelonephritis in Children

Navigating childhood illnesses can be a daunting task for parents, and pyelonephritis, a kidney infection, is a particularly serious condition. This research investigates the effectiveness of different antibiotic treatment regimens for pyelonephritis in children, comparing the efficacy of oral ceftibuten to sequential intravenous/oral ceftriaxone/ceftibuten. The researchers conducted a randomized multi-center trial to assess the impact of these treatments on renal scarring, a potential long-term consequence of pyelonephritis.

Oral Ceftibuten: A Viable Option for Pyelonephritis

The study revealed that oral ceftibuten administered for 14 days yielded comparable results to the sequential intravenous/oral regimen, suggesting that oral therapy can be a safe and effective treatment option for children with pyelonephritis. This finding is particularly noteworthy as it allows for outpatient management, reducing the need for hospitalization and minimizing the disruption to the child's life.

Minimizing the Impact of Pyelonephritis

This research provides valuable insights into the management of pyelonephritis in children, offering a less invasive treatment option that can be effectively delivered in an outpatient setting. By adopting this approach, we can minimize the burden of illness on children and their families, ensuring that they receive timely and effective care without the need for prolonged hospitalization.

Dr. Camel's Conclusion

This research provides a valuable tool for pediatricians managing children with pyelonephritis. The findings highlight the efficacy of oral ceftibuten and its potential to improve patient outcomes while reducing the need for hospitalization. It's a reminder that we must continually seek innovative approaches to treatment, ensuring that children receive the best possible care while minimizing the disruption to their lives.

Date :
  1. Date Completed 2009-01-22
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18074149

DOI: Digital Object Identifier

10.1007/s00431-007-0638-1

SNS
PICO Info
in preparation
Languages

English

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