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Metabolic and cardiovascular effects of carbuterol and metaproterenol.

Author: BeeD E, EllisS, GrantJ A, PotterD E, SandersJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Carbuterol, a selective beta-adrenergic bronchodilator, was well tolerated in a dose of 2 mg, but a 4-mg dose produced significant metabolic and cardiovascular effects. Metaproterenol also produced metabolic and cardiovascular effects.
Paper Details　
Original Abstract of the Article :
Metabolic and cardiovascular responses to selective beta-adrenergic bronchodilators, carbuterol and metaproterenol, were studied during an asymptomatic period in 8 male subjects with bronchial asthma diagnosed as mile to moderate. On separate days each individual received either placebo, carbuterol ...See full text at original site
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引用元：
https://doi.org/10.1016/0091-6749(77)90121-x

データ提供：米国国立医学図書館（NLM）

Bronchodilators: A Breath of Fresh Air

As researchers journey through the vast desert of respiratory illnesses, they are constantly searching for oases of effective treatments. This study, published in 1979, focuses on the effects of carbuterol and metaproterenol, two selective beta-adrenergic bronchodilators, on the respiratory system. These drugs work like desert winds, opening up the airways and making it easier to breathe. The researchers studied the metabolic and cardiovascular effects of these bronchodilators in eight male subjects with asthma.

Carbuterol: A Gentle Breeze

The study discovered that carbuterol, in a lower dosage (2 mg), was well-tolerated and showed minimal side effects. However, a higher dosage (4 mg) led to noticeable increases in glucose, insulin, and other metabolic markers. This finding suggests that lower dosages of carbuterol, like a gentle breeze, can provide relief without causing significant side effects.

Navigating the Side Effects

It's important to remember that every camel reacts differently to the desert environment. Some individuals may experience side effects, especially with higher dosages of carbuterol or metaproterenol. It's crucial to discuss your individual needs with your healthcare professional to determine the most appropriate dosage and treatment plan.

Dr. Camel's Conclusion

This study, like a caravan navigating a vast desert, provides valuable insights into the effects of selective beta-adrenergic bronchodilators. The research underscores the importance of finding the right dosage and treatment approach to optimize respiratory health and minimize potential side effects.
Date :
  1. Date Completed 1977-10-20
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

19514

DOI: Digital Object Identifier

10.1016/0091-6749(77)90121-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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