Paper Details

  1. Home
  2. Paper Details

Use of risk stratification to target therapies in patients with recent onset arthritis; design of a prospective randomized multicenter controlled trial.

Author: ClaessenSusanne J J, HazesJohanna M W, HuismanMargriet A M, LuimeJolanda J, WeelAngelique E A M, van ZebenDerkjen

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Early and intensive treatment is key for achieving remission and preventing joint damage in people with rheumatoid arthritis. While combined treatments are most effective, doctors often start with methotrexate and short-term steroids. Intensive treatment should begin as soon as the first symptoms appear, but at this early stage, the criteria for diagnosis might not be met, which could lead to overtreatment. This study aims to determine the best initial treatment for people with early signs of persistent arthritis. To avoid both overtreatment and undertreatment, the intensity of treatment will be based on a prediction model that identifies people who are likely to develop persistent arthritis.
Paper Details　
Original Abstract of the Article :
Early and intensive treatment is important to inducing remission and preventing joint damage in patients with rheumatoid arthritis. While intensive combination therapy (Disease Modifying Anti-rheumatic Drugs and/or biologicals) is the most effective, rheumatologists in daily clinical practice prefer...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702315/

データ提供：米国国立医学図書館（NLM）

Targeting Therapies in Early Arthritis: A Prospective Trial

Early and aggressive treatment is crucial for managing rheumatoid arthritis (RA) and preventing joint damage. This study explores the design of a prospective randomized multicenter controlled trial to determine the most effective induction therapy for patients with recent-onset persistent arthritis. The researchers aim to develop a prediction model that can identify patients at higher risk for persistent arthritis, allowing for tailored treatment strategies.

Personalized Arthritis Treatment: A Promising Approach

This study highlights the potential of personalized medicine in managing RA.

Effective Arthritis Management: Early Intervention is Key

The study underscores the importance of early and aggressive treatment in managing RA to minimize joint damage and improve patient outcomes.

Dr.Camel's Conclusion

This study proposes a novel approach to managing RA by tailoring treatment intensity based on individual risk factors.

Date :
  1. Date Completed 2009-08-21
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19538718

DOI: Digital Object Identifier

PMC2702315

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.