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Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures.

Author: DikmenS S, MachamerJ, MillerB, TemkinN R, WinnH R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Phenytoin had negative cognitive effects in severely injured patients, raising concerns about its long-term use for preventing posttraumatic seizures.
Paper Details　
Original Abstract of the Article :
In order to determine potential negative neurobehavioral effects of phenytoin given to prevent the development of posttraumatic seizures, 244 subjects were randomized to phenytoin or placebo. They received neurobehavioral assessments at 1 and 12 months postinjury while receiving their assigned drug ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1995974

データ提供：米国国立医学図書館（NLM）

Phenytoin Prophylaxis: A Tricky Path Through the Desert of Seizures

This study investigates the potential neurobehavioral effects of phenytoin, an anticonvulsant drug, used to prevent post-traumatic seizures. Imagine a caravan traversing a desert filled with hidden dangers, and each member needs to be protected from potential harm. This research explores the potential side effects of using phenytoin to prevent seizures after a traumatic brain injury.

Phenytoin: A Protective Barrier with Potential Side Effects

The study found that phenytoin significantly impaired performance in severely injured patients at 1 month after the injury. However, no significant differences were found in moderately injured patients or in either group at 1 year. This is like using a protective shield to safeguard the caravan from a sandstorm, but the shield itself might cause some minor discomfort or limitations. The study suggests that the use of phenytoin should be carefully considered, especially in the early stages after a traumatic brain injury.

Post-Traumatic Seizures: Navigating the Desert of Recovery

The study highlights the importance of balancing the risks and benefits of using phenytoin for post-traumatic seizure prophylaxis. It's like choosing the right path through a desert with both hidden dangers and potential opportunities. While phenytoin can be a valuable tool for preventing seizures, its potential side effects should be carefully considered, and alternative approaches may be more suitable in certain situations. This study underscores the need for individualized treatment plans and ongoing monitoring to ensure the best possible outcome for patients.

Dr.Camel's Conclusion

This study delves into the potential benefits and risks of using phenytoin to prevent post-traumatic seizures. It's like navigating a desert where each step must be carefully considered, balancing the need for protection with the potential for side effects. The study emphasizes the importance of individualized treatment plans and ongoing monitoring to ensure the best possible outcome for patients. Remember, every camel's journey through the desert of recovery is unique, and finding the right path requires careful consideration and guidance from experienced professionals.

Date :
  1. Date Completed 1991-03-25
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

1995974

DOI: Digital Object Identifier

1995974

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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