Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study.

Author: AntoninoMark J, BlidenKevin P, ButlerKathleen, EikelboomJohn W, GurbelPaul A, HendersonDavid, HustedSteen, KereiakesDean J, NielsenTonny, PatelDharmendra V, RasmussenLars, Sabe-AffakiGeorges, StoreyRobert F, TantryUdaya S, TengRenli, WeiCheryl

Paper Details 
Original Abstract of the Article :
BACKGROUND: The antiplatelet effects of the Platelet Inhibition and Patient Outcomes (PLATO) trial dose of ticagrelor in patients nonresponsive to clopidogrel and after they switch agents are unknown. METHODS AND RESULTS: Patients with stable coronary artery disease on aspirin therapy received a 30...See full text at original site
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引用元:
https://doi.org/10.1161/CIRCULATIONAHA.109.919456

データ提供:米国国立医学図書館(NLM)

Ticagrelor: A Promising Alternative for Clopidogrel Nonresponders

This study explores the effectiveness of ticagrelor, a new antiplatelet medication, in patients who do not respond adequately to clopidogrel, a commonly used antiplatelet drug. The study investigates the antiplatelet effects of ticagrelor in both clopidogrel responders and nonresponders, examining the potential of switching therapies.

Overcoming Clopidogrel Nonresponsiveness with Ticagrelor

The study demonstrated that ticagrelor effectively overcomes nonresponsiveness to clopidogrel, significantly reducing platelet aggregation in patients who did not adequately respond to clopidogrel. This finding suggests that ticagrelor could be a valuable alternative for patients who are not adequately protected by clopidogrel alone.

Improved Cardiovascular Protection for High-Risk Patients

This research offers hope for individuals at high risk of cardiovascular events by providing a more effective antiplatelet treatment option for those who do not respond adequately to clopidogrel. By exploring the efficacy of ticagrelor, the study paves the way for more personalized treatment strategies tailored to individual patient needs and responses.

Dr. Camel's Conclusion

This study, like a camel caravan traversing the treacherous desert of cardiovascular disease, explores the potential of ticagrelor as a lifeline for patients who do not respond adequately to clopidogrel. The findings, like a refreshing oasis in a parched landscape, highlight the efficacy of ticagrelor in overcoming nonresponsiveness to clopidogrel, offering hope for improved cardiovascular protection for those at high risk.

Date :
  1. Date Completed 2010-04-07
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20194878

DOI: Digital Object Identifier

10.1161/CIRCULATIONAHA.109.919456

Related Literature

SNS
PICO Info
in preparation
Languages

English

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