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Abnormal low density lipoproteins in children with familial hypercholesterolemia--effect of polyanion exchange resins.

Author: HeuckC C, MordasiniR, OsterP, RaetzerH, SchellenbergB, SchlierfG, TwelsiekF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Polyanion exchange resins were used to treat 20 children and adolescents with familial Type IIa hyperlipoproteinemia. The most common side effects were gastrointestinal discomfort and constipation. The resins reduced total and LDL cholesterol and Apo-B, but did not alter the abnormal LDL composition. HDL cholesterol remained low during treatment.
Paper Details　
Original Abstract of the Article :
In 20 children and adolescents with familial Type II a hyperlipoproteinemia, serum lipids and lipoproteins were examined before and during treatment with polyanion exchange resins. The composition of LDL was compared to that of helthy siblings. The patients were given Colestyramine (0.6 g/kg body we...See full text at original site
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引用元：
https://doi.org/10.1007/BF01489714

データ提供：米国国立医学図書館（NLM）

Exploring the Complexities of Familial Hypercholesterolemia

The world of [lipid metabolism] is filled with intricacies, and familial hypercholesterolemia (FH) is a prime example. This research investigates the [abnormal low-density lipoprotein (LDL) composition] in children with FH and the effects of polyanion exchange resins on lipid profiles. The authors use [a cross-over study] to compare the efficacy of colestyramine and colestipol in managing FH.

Unveiling the LDL Mystery

The study found that [LDL triglyceride: Apo-B ratio was about 50% lower in the patients] compared to healthy siblings. This finding highlights the [unique characteristics of LDL in FH patients]. Despite [treatment with polyanion exchange resins], the abnormal LDL composition remained unchanged. This suggests that [alternative therapeutic approaches] may be necessary to address the specific lipid abnormalities associated with FH.

The Importance of Early Intervention

The research highlights the importance of [early intervention] in managing FH. While polyanion exchange resins can [effectively reduce total and LDL cholesterol], they may not be sufficient to fully address the underlying lipid abnormalities. This underscores the need for a [multifaceted approach] to managing FH, including [lifestyle modifications, dietary interventions, and potentially other medications]. Just as oases provide a respite from the harsh desert environment, effective management of FH is crucial for maintaining health and well-being.

Dr.Camel's Conclusion

FH is a complex genetic disorder that requires a comprehensive approach to management. While polyanion exchange resins can help control cholesterol levels, they may not address all the lipid abnormalities associated with the condition. This research underscores the need for ongoing research into [novel therapies] and emphasizes the importance of [early intervention and personalized care] for individuals with FH.

Date :
  1. Date Completed 1978-11-29
  2. Date Revised 2019-07-11
Further Info :

Pubmed ID

211316

DOI: Digital Object Identifier

10.1007/BF01489714

SNS
PICO Info
in preparation
Languages

English

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