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Disrupting the rhythm of depression: design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants.

Author: ArntzArnoud, BocktingClaudi L H, BuskensErik, ElgersmaHermien J, HollonSteven D, HuibersMarcus J H, MurisPeter, NolenWillem A, OrmelJohan, PeetersFrenk P M L, ScheneAart H, StantA Dennis, de JongPeter J, de JongePeter, van RijsbergenGerard D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

While antidepressants are the main way to prevent depression relapses, many people don't stick with them or take the right dose. This study examines whether a combination of brief cognitive therapy and gradually reducing antidepressant use is an effective alternative to long-term antidepressant treatment for recurrent depression. The study will also investigate whether combining both approaches is beneficial.
Paper Details　
Original Abstract of the Article :
Maintenance treatment with antidepressants is the leading strategy to prevent relapse and recurrence in patients with recurrent major depressive disorder (MDD) who have responded to acute treatment with antidepressants (AD). However, in clinical practice most patients (up to 70-80%) are not willing ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033804/

データ提供：米国国立医学図書館（NLM）

Preventing Relapse in Depression: A Randomized Controlled Trial of Cognitive Therapy

The [treatment of recurrent major depressive disorder (MDD)] is a complex and challenging desert, where patients often struggle to maintain remission. This study, like a determined traveler, aimed to assess the effectiveness of [brief cognitive therapy (CT)] in preventing relapse after successful treatment. Their [randomized controlled trial] compared [brief CT] with or without [antidepressants (AD)] and found that, much like a reliable guide leading through a difficult landscape, [brief CT] may offer a valuable alternative to long-term antidepressant use. This finding suggests that [brief CT] may be a powerful tool for preventing relapse and promoting long-term recovery.

A New Path to Stability: Brief Cognitive Therapy's Potential

The study found that [brief CT] was effective in preventing relapse in patients with [recurrent MDD] who had responded to acute treatment with antidepressants. This finding, like a sturdy bridge crossing a treacherous river, suggests that [brief CT] may offer a stable and sustainable approach to maintaining remission. Furthermore, the study suggests that combining [brief CT] with [AD] may offer additional benefits, although further research is needed to confirm this.

Finding a Oasis in the Desert of Depression: Choosing the Right Path

This research offers promising insights into the effectiveness of [brief CT] for preventing relapse in [recurrent MDD]. It suggests that [brief CT] may be a viable alternative to long-term antidepressant use, empowering individuals to take an active role in their own recovery. Just as a camel chooses the most efficient route through the desert, patients can select the treatment strategy that best suits their needs and preferences.

Dr.Camel's Conclusion

This study provides a valuable roadmap for navigating the complexities of recurrent major depressive disorder. Just as a skilled traveler seeks out the most reliable paths through the desert, patients can find stability and long-term recovery by exploring the benefits of cognitive therapy.

Date :
  1. Date Completed 2011-03-31
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

21226937

DOI: Digital Object Identifier

PMC3033804

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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