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Studies on In situ Hydrogel: A Smart Way for Safe and Sustained Ocular Drug Delivery.

Author: ParikhRk, PatelLd, ShastriDh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study aimed to develop an ophthalmic in situ gelling system that reduces eye irritation caused by high concentrations of the gelling polymer Pluronic F 127. By combining PF127 with other polymers like hydroxypropyl methylcellulose, carbopol 940, xanthan gum, and sodium alginate, the researchers were able to reduce the concentration of individual polymers while maintaining the in vitro gelling capacity and rheology of the system. The optimized formulations showed sustained drug release over 10 hours and were unaffected by sterilization.
Paper Details　
Original Abstract of the Article :
The present work describes the formulation development of ophthalmic in situ gelling system using thermo-reversible gelling polymer, i.e. Pluronic F 127 (PF127). Because of high concentration (20 to 25%w/v) of this polymer required for in situ gelation causes irritation to the eye. So, to reduce thi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021684/

データ提供：米国国立医学図書館（NLM）

A Smart Approach to Eye Care: In Situ Hydrogel for Drug Delivery

The eye, a delicate window to the world, often requires special care, particularly when it comes to delivering medications. This research explores a novel approach to ocular drug delivery, utilizing a smart material called in situ hydrogel. The researchers investigated the potential of this innovative system to deliver medications in a safe and sustained manner, offering a beacon of hope in the desert of eye care.

A Smart Solution for a Sensitive Organ

The researchers found that the in situ hydrogel, formed from a combination of polymers, offers a promising way to deliver medications to the eye. The key to this system is its ability to transition from a liquid to a gel upon contact with the eye, allowing for controlled and sustained drug release. This approach not only enhances the effectiveness of the medication but also minimizes irritation, making it a more comfortable experience for the patient.

Protecting the Eye's Oasis

This research presents a smart solution for protecting the delicate oasis of the eye. By delivering medications in a safe and sustained manner, the in situ hydrogel system holds potential to improve patient outcomes and enhance their quality of life. It is a testament to the ingenuity of researchers and their commitment to finding innovative solutions for improving healthcare.

Dr.Camel's Conclusion

This research illustrates how scientific ingenuity can transform the way we deliver medications to the eye. By harnessing the power of in situ hydrogels, we can offer a more effective and comfortable treatment experience for patients. This study reminds us that in the vast desert of medical innovation, there is always room for new and exciting discoveries, ultimately leading to better patient care.

Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21264112

DOI: Digital Object Identifier

PMC3021684

SNS
PICO Info
in preparation
Languages

English

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