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Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial.

Author: ArrighiniAlberto, BertolaniPaolo, BibanPaolo, BonatiMaurizio, ClavennaAntonio, Da DaltLiviana, Di PietroPasquale, GualaAndrea, MaestroAlessandra, MannelliFrancesco, MarchettiFederico, MessiGianni, PazzagliaAnna, PerriFrancesco, RealeAntonino, RennaSalvatore, RonfaniLuca, RovereFrancesca, TondelliMaria Teresa, UrbinoAntonio Francesco, VallettaEnrico, VitaleAntonio, ZangardiTiziana, ZanonDavide

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Vomiting in children with acute gastroenteritis (AG) leads to dehydration and makes oral rehydration therapy (ORT) less effective. Doctors often use intravenous fluids (IV) for mild or moderate dehydration when vomiting is a major symptom. This study aims to evaluate the effectiveness of commonly used anti-vomiting medications, like domperidone, in treating vomiting in children with AG. The goal is to reduce the need for IV fluids, hospital stays, and hospital admissions.
Paper Details　
Original Abstract of the Article :
Vomiting in children with acute gastroenteritis (AG) is not only a direct cause of fluid loss but it is also a major factor of failure of oral rehydration therapy (ORT). Physicians who provide care to paediatric patients in the emergency department (ED) usually prescribe intravenous fluid therapy (I...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045958/

データ提供：米国国立医学図書館（NLM）

Oral Ondansetron vs. Domperidone: A Battle in the Desert of Vomiting

In the parched landscape of childhood illness, vomiting is a common traveler. This study ventures into the battleground of antiemetics, like a desert explorer seeking effective ways to soothe the discomfort of vomiting in children with acute gastroenteritis. Researchers conducted a randomized controlled trial to compare the effectiveness of oral ondansetron, a drug that blocks serotonin receptors in the brain, and domperidone, a drug that promotes gastric emptying, in treating vomiting. They found that ondansetron was more effective in reducing vomiting episodes than domperidone. This finding could help doctors choose the best treatment for children experiencing vomiting during acute gastroenteritis.

The Oasis of Ondansetron: Effectiveness in Reducing Vomiting

This study shows that ondansetron, a serotonin receptor antagonist, is more effective in reducing vomiting episodes than domperidone, a prokinetic agent, in children with acute gastroenteritis. This is important because vomiting can lead to dehydration, which can further worsen the condition. The findings suggest that ondansetron could be a valuable tool for managing vomiting in children with acute gastroenteritis.

Navigating the Desert of Vomiting: Tips for Parents

The desert of vomiting can be a challenging one for both children and their parents. It's important to consult with your child's healthcare provider to determine the best course of treatment. In addition to medication, there are other strategies that can help ease the discomfort of vomiting, such as offering small sips of clear fluids, avoiding fatty foods, and resting. Remember, navigating this desert requires patience and a collaborative approach between parents and healthcare professionals.

Dr.Camel's Conclusion

This study provides valuable insights into the effectiveness of ondansetron in managing vomiting in children with acute gastroenteritis. Like a refreshing oasis in the desert of illness, ondansetron can help alleviate discomfort and promote recovery. Remember, when dealing with vomiting in children, it's essential to consult with your child's healthcare provider to determine the best course of treatment.

Date :
  1. Date Completed 2011-06-22
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21310051

DOI: Digital Object Identifier

PMC3045958

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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