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Progesterone vs placebo therapy for women with epilepsy: A randomized clinical trial.

Author: , DworetzkyB A, FowlerK M, HardenC L, HeckC N, HerzogA G, KalayjianL A, LiporaceJ D, MassaroJ M, PennellP B, SmithsonS D, SperlingM R

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Cyclic progesterone was ineffective in women with intractable partial epilepsy. However, post hoc analysis suggested that a subset of women with higher levels of perimenstrual seizure exacerbation responded to treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess progesterone treatment of intractable seizures in women with partial epilepsy. METHODS: This randomized, double-blind, placebo-controlled, phase III, multicenter, clinical trial compared the efficacy and safety of adjunctive cyclic natural progesterone therapy vs placebo treatm...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369508/

データ提供：米国国立医学図書館（NLM）

Progesterone's Role in Epilepsy: A Sandstorm of Hormones

The study delves into the complex and often unpredictable world of epilepsy, a condition that causes seizures. This study focuses on women who experience seizures that are particularly severe around their menstrual cycle, like a sandstorm hitting with unpredictable force. Researchers investigated whether progesterone, a hormone naturally involved in the menstrual cycle, could help manage these seizures. The study involved a large group of women with epilepsy and compared the effects of taking progesterone versus a placebo. The results showed that progesterone did not significantly reduce the overall frequency of seizures for all women. However, a closer look revealed that progesterone might be beneficial for women who experience a particularly intense surge in seizures around their menstrual cycle. It's like a sandstorm that is more powerful on certain days.

A Glimpse of Hope in the Desert

While progesterone didn't provide a universal solution, the study suggests that it might offer hope for a specific subset of women with epilepsy. This finding is significant because it highlights the importance of personalized approaches to treatment, recognizing that each individual's experience is unique. It's like finding a single oasis in a vast desert, offering a beacon of hope for those who need it most.

Understanding Your Body's Rhythms

If you are a woman with epilepsy, it's crucial to understand your individual patterns and triggers. Keeping track of your menstrual cycle and the frequency of your seizures can be a valuable tool for managing your condition. This research emphasizes the importance of open communication with your healthcare provider to explore personalized treatment options. Like navigating a desert, understanding your body's rhythms can guide you towards better health and well-being.

Dr. Camel's Conclusion

This research, like a desert oasis, offers a glimmer of hope for women with epilepsy who experience seizures exacerbated by their menstrual cycle. While progesterone may not be a cure-all, it highlights the importance of personalized approaches to treatment and understanding the unique rhythms of our bodies.
Date :
  1. Date Completed 2012-08-20
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22649214

DOI: Digital Object Identifier

PMC3369508

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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