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Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.

Author: , BachFriedhelm, BloosFrank, BogatschHolger, BrunkhorstFrank M, BüchlerMarkus W, EngelChristoph, FritzHarald, GründlingMatthias, JaschinskiUlrich, JohnStefan, KiehntopfMichael, KollefMarin H, KuhntEvelyn, LoefflerMarkus, LudewigKatrin, MarxGernot, Meier-HellmannAndreas, MoererOnnen, NierhausAxel, OppertMichael, PutensenChristian, RagallerMaximilian, ReillLorenz, ReinhartKonrad, RiessenReimer, SeibelArmin, SpiesClaudia, WelteTobias, WeylandAndreas

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Treatment with combined meropenem and moxifloxacin compared with meropenem alone did not result in less organ failure in adult patients with severe sepsis. There was no statistically significant difference in the rates of 28-day and 90-day mortality between the two groups.
Paper Details　
Original Abstract of the Article :
CONTEXT: Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial. OBJECTIVE: To compare the effect of moxifloxacin and meropenem wi...See full text at original site
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引用元：
https://doi.org/10.1001/jama.2012.5833

データ提供：米国国立医学図書館（NLM）

Antibiotics for Sepsis: A Comparative Study

The field of critical care is constantly seeking better treatments for life-threatening infections like sepsis. This study examined the effectiveness of different antibiotic combinations in patients with severe sepsis. The researchers conducted a randomized controlled trial to compare the effects of moxifloxacin and meropenem versus meropenem alone. It is like testing different strategies for navigating a treacherous desert.

The study found that there was no significant difference in the effectiveness of the two antibiotic regimens in terms of reducing organ failure or mortality. The findings suggest that both regimens may be equally effective in treating severe sepsis.

Antibiotic Strategies for Sepsis

The findings suggest that both moxifloxacin and meropenem, either alone or in combination, can be effective in treating severe sepsis. The study provides valuable information for guiding antibiotic treatment decisions in this critical care setting.

Managing Sepsis

This research highlights the importance of early and appropriate antibiotic therapy in managing severe sepsis. It underscores the need for ongoing research to optimize treatment strategies for this life-threatening condition.

Dr.Camel's Conclusion

This study offers valuable insights into the complex world of antibiotic therapy for severe sepsis. It emphasizes the need for careful patient assessment and the importance of choosing the appropriate antibiotic regimen based on individual needs.

Date :
  1. Date Completed 2012-06-15
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

22692171

DOI: Digital Object Identifier

10.1001/jama.2012.5833

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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