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Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
Author: AngiolilloDominick J, BakerBrian A, HeiselmanDarell E, JakubowskiJoseph A, LiWei, LoganDouglas K, PriceMatthew J, WalderJames S, WintersKenneth J
Original Abstract of the Article :
OBJECTIVES: The goal of this study was to assess the offset of the antiplatelet effects of prasugrel and clopidogrel. BACKGROUND: Guidelines recommend discontinuing clopidogrel at least 5 days and prasugrel at least 7 days before surgery. The pharmacodynamic basis for these recommendations is limit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.jacc.2012.02.042
データ提供:米国国立医学図書館(NLM)
Recovering from Antiplatelet Treatment: A Desert of Platelet Activity
Imagine your platelets as a caravan traveling through the desert, responsible for clotting and stopping bleeding. Antiplatelet medications are like sandstorms, slowing down this caravan and making it harder to stop bleeding. This research explores the recovery of platelet function after stopping two common antiplatelet medications, prasugrel and clopidogrel. The authors investigated how long it takes for platelet function to return to normal after these medications are discontinued, especially before surgery.
The Oasis of Platelet Recovery
The study found that the recovery time after discontinuing thienopyridines, like prasugrel and clopidogrel, depends on the initial degree of platelet inhibition. It's like understanding how the strength of a sandstorm affects how long it takes for the caravan to resume its normal journey. This research provides valuable information for clinicians when deciding on the appropriate waiting period for surgery after stopping these medications.
Navigating the Shifting Sands of Antiplatelet Therapy
This research sheds light on the complexities of antiplatelet therapy. It's like navigating the ever-changing landscape of a desert, understanding the impact of these medications on platelet function and the importance of timing when it comes to surgery. Consulting with a healthcare professional is crucial for making informed decisions about antiplatelet therapy and minimizing potential risks.
Dr. Camel's Conclusion
The research on antiplatelet recovery highlights the intricate dynamics of platelet function. It's like studying the ebb and flow of sand in the desert, understanding how these medications affect clotting and the importance of careful planning when it comes to surgery. By understanding the nuances of antiplatelet therapy, we can navigate the desert of platelet activity with greater confidence and safety.
Date :
- Date Completed 2012-08-20
- Date Revised 2019-12-10
Further Info :
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