Clinical efficacy and safety of the newer antiepileptic drugs as adjunctive treatment in adults with refractory partial-onset epilepsy: a meta-analysis of randomized placebo-controlled trials.

Author: GaoLan, LiShu-Chuen, XiaLi, ZhaoFei-Li

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate the clinical efficacy and safety of the newer antiepileptic drugs (AEDs), namely, Eslicarbazepine (ESL), Retigabine/Ezogabine (RTG), Carisbamate (CAR), Lacosamide (LAC), Brivaracetam (BRI) or Perampanel (PER) as adjunctive therapy for adults with partial-onset seizures (POS). ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.eplepsyres.2012.06.005

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Epilepsy: Exploring Newer Antiepileptic Drugs

The desert of epilepsy is a complex landscape, with patients facing a range of challenges in managing their seizures. This study explores the efficacy and safety of newer antiepileptic drugs (AEDs) as adjunctive therapy for adults with refractory partial-onset seizures. The researchers conducted a meta-analysis, combining data from multiple clinical trials to evaluate the effectiveness of these newer medications.

A Diverse Oasis of Treatment

The meta-analysis found that newer AEDs, like a diverse oasis in the desert, were more effective than placebo in reducing seizures. However, the study also found that these newer medications were associated with a higher incidence of adverse effects. This highlights the importance of balancing efficacy and safety when considering treatment options for epilepsy.

Finding the Right Path in the Desert of Epilepsy

This research offers a valuable overview of newer AEDs for managing epilepsy. It underscores the importance of considering the individual patient's needs and risks when choosing a treatment.

Dr.Camel's Conclusion

This study offers valuable insights into the landscape of newer AEDs for managing epilepsy. It emphasizes the importance of carefully weighing the benefits and risks of these medications, like navigating through a desert, to find the right treatment path for each patient.

Date :
  1. Date Completed 2013-10-17
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

22776828

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2012.06.005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.