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Central effects of the angiotensin-converting enzyme inhibitor, captopril. I. Performance and subjective assessments of mood.

Author: CurrieD, LewisR V, McDevittD G, NicholsonA N, WrightN A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Captopril does not impair performance or mood in healthy subjects and may be a suitable treatment for hypertensive patients engaged in skilled activity.
Paper Details　
Original Abstract of the Article :
1. Central effects of single doses of captopril (12.5, 25 and 50 mg) were studied in fourteen healthy male subjects. Two placebos and an active control drug, oxazepam (15 mg), were included, together with a single dose of atenolol (100 mg). The drugs were administered double-blind at 11.00 h, and pe...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1365-2125.1990.tb03810.x

データ提供：米国国立医学図書館（NLM）

Captopril's Central Effects: A Journey Through the Desert of Cognitive Function

The quest for understanding the effects of medications on the brain is a continuous journey, and researchers are constantly exploring the complex interplay between drugs and cognitive function. This research delves into the central effects of [captopril], an angiotensin-converting enzyme inhibitor, on cognitive performance and subjective mood. The authors conducted a study on healthy male subjects, investigating the potential impact of captopril on a range of cognitive tasks and mood assessments.

A Serene Oasis: Captopril's Potential Benefits

The study found that captopril did not impair performance on any of the cognitive tasks tested. In fact, it even improved short-term memory and increased the number of letters cancelled in a letter cancellation task. These findings are like discovering a serene oasis in the vast desert of cognitive function, suggesting that captopril may have potential cognitive benefits. The study also found no adverse effects on mood or subjective well-being, further supporting the safety of captopril for individuals engaged in skilled activities.

Navigating the Desert of Cognitive Function: The Importance of Personalized Treatment

This research provides valuable insights into the potential central effects of captopril on cognitive function and mood. The study's findings suggest that captopril might offer a safe and potentially beneficial option for hypertensive patients who engage in skilled activities. It's like finding a new path through the desert of cognitive function, offering a glimmer of hope for those seeking to maintain cognitive health while managing hypertension.

Dr.Camel's Conclusion

This research sheds light on the potential central effects of captopril, suggesting that it may not only be effective in managing hypertension but also potentially beneficial for cognitive function. The study's findings are a reminder that even in the vast and challenging desert of medical research, new discoveries can lead to a better understanding of the intricate interplay between medications and cognitive health.

Date :
  1. Date Completed 1991-04-09
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2291867

DOI: Digital Object Identifier

10.1111/j.1365-2125.1990.tb03810.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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