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Effects of amlodipine on the oral bioavailability of cephalexin and cefuroxime axetil in healthy volunteers.

Author: DingLiKun, DingYi, JiaYanYan, JinXin, LiuWenXing, LuChengTao, SongYing, WenAiDong, YangJing, YangLin, ZhuYanRong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined the effect of the calcium channel blocker amlodipine on the absorption of two antibiotics, cephalexin and cefuroxime axetil. Amlodipine was found to increase the levels of cephalexin in the blood, suggesting a drug interaction. However, amlodipine did not affect the absorption of cefuroxime axetil. This finding suggests that the interaction between amlodipine and antibiotics may be specific to certain types of antibiotics.
Paper Details　
Original Abstract of the Article :
In this study, the authors compared the effects of amlodipine (AML) on the bioavailability of cephalexin (LEX) and cefuroxime axetil (CXM). Twenty-four healthy men were randomized to 4 treatments according to a crossover design with a 14-day washout. After an overnight fast, they were administered o...See full text at original site
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引用元：
https://doi.org/10.1177/0091270011435327

データ提供：米国国立医学図書館（NLM）

Amlodipine's Impact on Cephalexin and Cefuroxime Axetil Bioavailability

This research ventures into the fascinating realm of drug interactions, investigating how the calcium channel blocker amlodipine influences the absorption of two antibiotics, cephalexin and cefuroxime axetil. The authors meticulously designed a crossover study, like a skilled desert traveler switching paths to compare different routes, to examine the bioavailability of these medications when taken with or without amlodipine.

Enhanced Bioavailability of Cephalexin

The study's results revealed a fascinating phenomenon: amlodipine significantly boosted the bioavailability of cephalexin. This finding, much like a desert oasis providing vital nourishment, suggests that combining amlodipine with cephalexin could potentially enhance its therapeutic effectiveness.

Specific Interactions

The study also highlighted the specificity of this interaction, suggesting that amlodipine may not impact the bioavailability of all antibiotics. This intricate interplay, like a delicate dance between different desert plants, emphasizes the importance of understanding the unique relationships between drugs in the body.

Dr.Camel's Conclusion

This study underscores the complexity of drug interactions, emphasizing the importance of considering these interactions when prescribing medications. It reminds us that even seemingly unrelated drugs can have unexpected effects on each other, much like the intricate web of relationships within a desert ecosystem.
Date :
  1. Date Completed 2013-07-30
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

23400747

DOI: Digital Object Identifier

10.1177/0091270011435327

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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