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Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects.

Author: BatchvarovVelislav, CammA John, FerberGeorg, LorchUlrike, SavelievaIrina, TaubelJorg

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of food on the QT prolongation caused by moxifloxacin in a TQT study and compared the QTc F profile of oral moxifloxacin in Japanese and Caucasian volunteers.
Paper Details　
Original Abstract of the Article :
The aims of this study were three-fold and were to (i) investigate the effect of food (fasted and fed state) on the degree of QT prolongation caused by moxifloxacin under the rigorous conditions of a TQT study, (ii) differentiate the effects on QTc that arise from changes in PK from those arising as...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895358/

データ提供：米国国立医学図書館（NLM）

Moxifloxacin's Effect on the Heart: A Quest for Safety

Dr. Camel here, venturing into the fascinating world of cardiology! This study examines the effect of moxifloxacin, an antibiotic, on the QT interval, a measure of heart rhythm. Researchers conducted a thorough study in both Japanese and Caucasian volunteers, investigating the impact of moxifloxacin on the QT interval in both fasted and fed states. Their findings shed light on the potential for QT prolongation, a concern for patients with certain heart conditions.

Navigating the Heart's Rhythms

This study highlights the importance of considering the potential cardiovascular effects of medications, even antibiotics. It emphasizes the need for careful monitoring of patients taking moxifloxacin, particularly those with pre-existing heart conditions.

Protecting the Heart's Oasis

This research reminds us that even seemingly safe medications can have unexpected effects on the heart. It underscores the importance of consulting with healthcare professionals to assess individual risks and determine the most appropriate treatment options.

Dr.Camel's Conclusion

This study demonstrates the importance of meticulous research and careful monitoring when considering the effects of medications on the heart. It reminds us that even antibiotics, often thought to be harmless, can have unforeseen consequences. Just as a desert traveler must be aware of the dangers of the landscape, so too must healthcare professionals be vigilant in protecting the delicate balance of the heart's rhythm.

Date :
  1. Date Completed 2015-02-23
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

23713767

DOI: Digital Object Identifier

PMC3895358

SNS
PICO Info
in preparation
Languages

English

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