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[Pharmacokinetic and clinical evaluations of aztreonam monotherapy and aztreonam and ampicillin combination therapy in neonates and premature infants].

Author: AramakiM, KawakamiA, KogaT, MotohiroT, OdaK, SakataY, ShimadaY, TanakaK, TominagaK, TomitaS

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
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Overview

Aztreonam (AZT) was effective in treating and preventing infections in neonates and premature infants, with a well-tolerated side effect profile.
Paper Details　
Original Abstract of the Article :
One-shot intravenous injection of aztreonam (AZT), a monobactam-class beta-lactam antibiotic, 20 mg/kg was administered to 4 neonates and 2 premature infants, a total of 6 cases, and plasma and urinary concentrations and urinary recovery rates were determined. Also, one-shot intravenous injection av...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2374300

データ提供：米国国立医学図書館（NLM）

Exploring Aztreonam Therapy in Neonates and Premature Infants

The field of neonatal medicine is a vast desert, often navigating the challenges of administering medications to vulnerable infants. This study examines the pharmacokinetic and clinical effects of aztreonam, a monobactam-class beta-lactam antibiotic, in neonates and premature infants. The researchers explored the plasma and urinary concentrations of aztreonam when administered alone and in combination with ampicillin. They also evaluated the clinical effects, prophylactic efficacy, bacteriological effects, side effects, and clinical laboratory test values of these therapies. The study provides valuable insights into the safe and effective use of aztreonam in neonates and premature infants.

Aztreonam Shows Promise in Neonatal Treatment

This study demonstrates the potential of aztreonam as a safe and effective treatment option for neonates and premature infants. The research provides valuable insights into the pharmacokinetic and clinical effects of aztreonam in this vulnerable population. The findings suggest that aztreonam can be safely administered to neonates and premature infants, providing a valuable tool for treating infections in this delicate group.

A Beacon of Hope for Neonatal Care

The study highlights the importance of careful consideration of drug pharmacokinetics and clinical effects in neonates and premature infants. The research provides valuable information for physicians navigating the challenges of treating infections in this vulnerable population. The study's findings serve as a beacon of hope in the desert of neonatal medicine, offering valuable insights into the safe and effective use of aztreonam in this delicate group.

Dr.Camel's Conclusion

This study offers valuable insights into the pharmacokinetic and clinical effects of aztreonam in neonates and premature infants. The research demonstrates the potential of aztreonam as a safe and effective treatment option for infections in this vulnerable population. The study's findings provide valuable information for physicians navigating the challenges of treating infections in neonates and premature infants, offering a beacon of hope in the desert of neonatal medicine.

Date :
  1. Date Completed 1990-08-29
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

2374300

DOI: Digital Object Identifier

2374300

SNS
PICO Info
in preparation
Languages

Japanese

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