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Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group.

Author: DeWoodM A, WolbachR A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nicardipine and nifedipine are calcium channel blockers used to treat angina pectoris. This study compared the incidence of dizziness, flushing, headache, pedal edema, and palpitations. Patients who experienced these symptoms with nifedipine during a month-long open-label trial experienced a higher incidence of the same symptoms during a double-blind trial. Nicardipine was associated with a lower incidence of these side effects compared to nifedipine.
Paper Details　
Original Abstract of the Article :
Nicardipine and nifedipine are structurally similar dihydropyridine calcium channel blockers with demonstrated efficacy in the treatment of stable angina pectoris. The present study was a prospective randomized trial designed to evaluate the relative incidence of dizziness, flushing, headache, pedal...See full text at original site
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引用元：
https://doi.org/10.1016/s0002-8703(05)80071-7

データ提供：米国国立医学図書館（NLM）

Side Effects of Nicardipine and Nifedipine in Angina Pectoris

Angina pectoris, a condition characterized by chest pain due to insufficient blood flow to the heart, is often treated with calcium channel blockers. This study compares the side effects of two similar calcium channel blockers, nicardipine and nifedipine, in patients with angina. The researchers conducted a randomized, double-blind trial to evaluate the incidence of specific side effects, such as dizziness, flushing, headache, and edema. Their findings suggest that nicardipine may be associated with a lower incidence of these side effects compared to nifedipine.

Choosing the Right Path: Navigating Calcium Channel Blockers for Angina

The study's findings highlight the importance of considering potential side effects when choosing a calcium channel blocker for angina. Nicardipine, with its lower incidence of common side effects, may be a preferred option for some patients. However, individualized assessment and close monitoring are crucial to ensure optimal treatment outcomes.

Managing Angina: A Balancing Act of Benefits and Risks

Angina pectoris can be a distressing condition, but with proper management, you can live a fulfilling life. This study underscores the importance of considering both the benefits and potential risks of various treatment options, including the side effects of medications. Talk to your doctor to discuss the best treatment strategy for your individual needs and preferences.

Dr. Camel's Conclusion

This research highlights the importance of considering the nuances of medication side effects, even when dealing with similar drugs. Much like navigating a desert landscape, each patient's experience with medication can be unique, and individualized care is crucial for achieving optimal outcomes.

Date :
  1. Date Completed 1990-03-13
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

2405616

DOI: Digital Object Identifier

10.1016/s0002-8703(05)80071-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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