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Systematic review of the side effects associated with tyrosine kinase inhibitors used in the treatment of gastrointestinal stromal tumours on behalf of the EORTC Quality of Life Group.

Author: BottomleyAndrew, EfficaceFabio, FitzsimmonsDeborah, JohnsonColin D, SodergrenSamantha C, SprangersMirjam, WhiteAlice

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of advanced gastrointestinal stromal tumors (GISTs), but they can have side effects. This review summarizes the safety profiles of imatinib and sunitinib, highlighting common side effects such as gastrointestinal complaints, edema, fatigue, and hematological disorders.
Paper Details　
Original Abstract of the Article :
Tyrosine kinase inhibitors (TKIs) have revolutionised the treatment of advanced gastrointestinal stromal tumours (GISTs). Imatinib is approved as first line therapy and sunitinib is used in cases of imatinib resistance or intolerance. Compared with conventional treatments, TKIs are delivered over lo...See full text at original site
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引用元：
https://doi.org/10.1016/j.critrevonc.2014.01.002

データ提供：米国国立医学図書館（NLM）

Tyrosine Kinase Inhibitors: A Double-Edged Sword in the Desert of Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs), like a sandstorm that can erupt suddenly and unexpectedly, can be a challenging condition to treat. This [systematic review] examines the side effects of tyrosine kinase inhibitors (TKIs), a class of drugs that target specific proteins involved in tumor growth, which are used to manage GISTs. The researchers provide a comprehensive overview of the side effects associated with two commonly used TKIs, imatinib and sunitinib, highlighting the need for careful monitoring and management. It's like navigating a desert with both breathtaking beauty and hidden dangers: TKIs offer a potent weapon against GISTs, but they come with their own set of potential risks.

Navigating the Side Effects of TKIs

The review provides a detailed overview of the side effects associated with imatinib and sunitinib, offering valuable information for patients and clinicians to make informed decisions about treatment.

Balancing Benefits and Risks

The review emphasizes the importance of carefully weighing the potential benefits and risks of TKI therapy in the management of GISTs.

Dr.Camel's Conclusion

TKIs have revolutionized the treatment of GISTs, offering a powerful weapon against these aggressive tumors. However, it's important to be aware of the potential side effects and to work closely with healthcare providers to manage any adverse effects effectively.

Date :
  1. Date Completed 2015-01-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24495942

DOI: Digital Object Identifier

10.1016/j.critrevonc.2014.01.002

SNS
PICO Info
in preparation
Languages

English

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