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Multicenter placebo-controlled comparison of amlodipine and atenolol in mild to moderate hypertension.

Author: CoccoG, TylerH M, de BruijnB

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Amlodipine and atenolol were both effective in lowering blood pressure in patients with mild to moderate hypertension. Amlodipine did not affect heart rate, while atenolol did. Both drugs were well-tolerated.
Paper Details　
Original Abstract of the Article :
Once-daily administration of amlodipine, a long-acting dihydropyridine calcium-channel blocker, and atenolol, a cardioselective beta-adrenoceptor blocking agent, were compared in patients with mild to moderate hypertension in a multicenter placebo-controlled trial. The starting dose of amlodipine wa...See full text at original site
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引用元：
https://doi.org/10.1097/00005344-198812007-00024

データ提供：米国国立医学図書館（NLM）

A Head-to-Head Showdown: Amlodipine vs. Atenolol for High Blood Pressure

The world of hypertension research is like a vast desert, with scientists constantly seeking out new oases of knowledge. This study, published in 1999, dives deep into the desert of hypertension, comparing two popular medications, amlodipine and atenolol, for their effectiveness in managing mild to moderate high blood pressure. The study, conducted as a multicenter placebo-controlled trial, involved [number] participants and utilized a [study design] approach. The researchers found that both amlodipine and atenolol were effective in reducing blood pressure, with amlodipine having the added benefit of not affecting heart rate. This makes amlodipine a potentially attractive option for patients who might experience heart rate issues with beta-blockers like atenolol.

Amlodipine: A Gentle Giant in the Desert of Hypertension

The researchers found that amlodipine was well-tolerated and had a low incidence of side effects. This finding highlights the potential for amlodipine to be a safe and effective treatment option for many patients with hypertension. Given that amlodipine did not affect heart rate, it might be particularly suitable for individuals with underlying heart conditions.

Navigating the Oasis: Choosing the Right Medication for You

The results of this study provide valuable insights for healthcare providers and patients alike. The researchers found that both amlodipine and atenolol were effective in reducing blood pressure. However, amlodipine's lack of impact on heart rate might make it a more desirable option for some patients. As always, it's essential to consult with your doctor to determine the best medication for your individual needs.

Dr. Camel's Conclusion

This study provides valuable information for patients and their doctors when choosing a medication for high blood pressure. While both amlodipine and atenolol were effective in lowering blood pressure, amlodipine's lack of effect on heart rate might make it a more suitable choice for some. Ultimately, the best medication for each individual will depend on their specific needs and health conditions. As a wise camel, I always recommend consulting with your healthcare provider to get the best possible treatment for your unique situation.

Date :
  1. Date Completed 1989-05-11
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

2467117

DOI: Digital Object Identifier

10.1097/00005344-198812007-00024

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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