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Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration.

Author: BuschStephanie, FengYuxi, GretzNorbert, HammesHans-Peter, HoffmannSigrid, KanntAimo, KolibabkaMatthias, LinJihong, SchlottererAndreas, WangQian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Erythropoietin (EPO) was found to protect the neuroglialvascular unit in a rat model of retinal neurodegeneration. EPO treatment significantly reduced the formation of acellular capillaries and protected against thinning of the central retina. Microglial activity was also decreased by EPO treatment. This study suggests that EPO may be beneficial in treating retinal neurodegeneration.
Paper Details　
Original Abstract of the Article :
Rats expressing a transgenic polycystic kidney disease (PKD) gene develop photoreceptor degeneration and subsequent vasoregression, as well as activation of retinal microglia and macroglia. To target the whole neuroglialvascular unit, neuro- and vasoprotective Erythropoietin (EPO) was intraperitonea...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094460/

データ提供：米国国立医学図書館（NLM）

Erythropoietin: A Protective Force for the Neurovascular Unit

This study investigates the protective effects of erythropoietin (EPO) on the neurovascular unit in a rat model of retinal neurodegeneration. The researchers examined the impact of systemic EPO treatment on retinal morphology, glial cell activity, and pAkt localization in rats expressing a transgenic polycystic kidney disease (PKD) gene. They observed that EPO treatment significantly reduced retinal degeneration, protected against thinning of the central retina, and decreased microglial activity. Their findings demonstrate the potential of EPO as a neuroprotective agent for treating retinal neurodegeneration.

Preserving the Integrity of the Neurovascular Unit

The study reveals the protective effects of EPO on the neurovascular unit in a model of retinal neurodegeneration. The researchers observed significant reductions in retinal degeneration and thinning of the central retina in rats treated with EPO. This suggests that EPO can preserve the integrity of the neurovascular unit, potentially delaying or preventing vision loss. The study’s findings offer promising avenues for developing new therapeutic strategies for treating retinal neurodegeneration.

Protecting Vision Health

This research highlights the potential of EPO as a neuroprotective agent for treating retinal neurodegeneration. While further research is needed to confirm these findings in humans, this study offers hope for developing new therapies to protect vision health. It’s essential to maintain a healthy lifestyle, including regular eye exams and early detection of any potential eye problems.

Dr.Camel's Conclusion

This study provides compelling evidence for the neuroprotective effects of EPO on the neurovascular unit in a model of retinal neurodegeneration. The researchers demonstrate that EPO can significantly reduce retinal degeneration and protect against thinning of the central retina. This research offers hope for developing new therapies to protect vision health and potentially delay or prevent vision loss.

Date :
  1. Date Completed 2015-03-04
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25013951

DOI: Digital Object Identifier

PMC4094460

SNS
PICO Info
in preparation
Languages

English

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