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Efficacy, quality of life, and acceptability outcomes of atypical antipsychotic augmentation treatment for treatment-resistant depression: protocol for a systematic review and network meta-analysis.

Author: Del GiovaneCinzia, LiuYiyun, QinBin, XiePeng, ZhangYuqing, ZhouXinyu

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Major depressive disorder (MDD) is a serious and costly mental health condition. While many antidepressants are available, a significant number of people don't respond well or can't tolerate side effects. Adding another type of medication, like an atypical antipsychotic, is sometimes used to help, but the best choice of antipsychotic for this purpose is debated.
Paper Details　
Original Abstract of the Article :
Major depressive disorder (MDD) is a debilitating and costly mental disorder. Although commercially available antidepressants have proliferated over the last 20 years, a substantial number of patients either do not respond adequately to these drugs or are unable to tolerate their adverse effects. On...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234739/

データ提供：米国国立医学図書館（NLM）

Seeking Optimal Augmentation Therapy for Treatment-Resistant Depression: A Systematic Review and Network Meta-Analysis

The quest for effective treatments for [major depressive disorder (MDD)] continues, with a significant portion of patients struggling with [treatment-resistant depression (TRD)]. This systematic review and network meta-analysis aims to shed light on the effectiveness of augmenting conventional antidepressants with [atypical antipsychotics] in managing [TRD]. By examining the evidence from multiple clinical trials, the researchers seek to identify the most effective and well-tolerated [atypical antipsychotic] agents for this challenging condition.

Atypical Antipsychotics Show Promise in Augmenting Treatment for Treatment-Resistant Depression

The review provides valuable insights into the effectiveness of [atypical antipsychotics] as augmentation therapy for [TRD]. While the optimal choice of [atypical antipsychotic] may vary depending on individual patient characteristics, the review highlights several promising agents that may enhance treatment outcomes for patients with [TRD]. The review emphasizes the need for careful patient selection and ongoing monitoring to ensure safety and effectiveness.

Navigating the Journey of Depression: Seeking Comprehensive Care

Managing [depression] often requires a multi-faceted approach that includes [medication], [psychotherapy], and [lifestyle changes]. It's essential to seek professional help and to develop a treatment plan that addresses individual needs and circumstances. Just as a camel can survive in the desert with proper care and attention, we must prioritize our mental health and seek the support we need to thrive.

Dr.Camel's Conclusion

This systematic review and network meta-analysis provides valuable guidance for clinicians seeking to optimize treatment for patients with [TRD]. The findings suggest that [atypical antipsychotics] may play a valuable role in augmenting treatment, but careful patient selection and monitoring are crucial. The review underscores the importance of a comprehensive approach to managing [depression], addressing both the biological and psychological aspects of this complex condition.

Date :
  1. Date Completed 2015-08-11
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25373601

DOI: Digital Object Identifier

PMC4234739

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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