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Buprenorphine for pain relief in mice: repeated injections vs sustained-release depot formulation.

Author: ArrasM, CinelliP, JirkofP, TourvieilleA

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared a sustained-release formulation of buprenorphine with a standard protocol of three injections of buprenorphine in mice.
Paper Details　
Original Abstract of the Article :
Sustained-release formulations of analgesic drugs are promising alternatives to repeated drug injections. Here, we compared a sustained-release formulation of buprenorphine (SB, 2.2 mg/kg) with a standard protocol of three injections of buprenorphine (Temgesic, 0.1 mg/kg/8 h) in mice. Buprenorphine ...See full text at original site
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引用元：
https://doi.org/10.1177/0023677214562849

データ提供：米国国立医学図書館（NLM）

Buprenorphine for Pain Relief: Comparing Delivery Methods

Sustained-release formulations of analgesic drugs offer a promising alternative to repeated injections. This study compares a sustained-release formulation of buprenorphine (SB) to a standard protocol of three injections of buprenorphine (Temgesic) in mice. The research aims to evaluate the efficacy and duration of action of these two delivery methods, assessing their impact on pain relief and potential side effects. The authors meticulously analyze the serum concentrations, analgesic action, and behavioral outcomes associated with both protocols, providing valuable insights into the optimal approach for managing pain in animal models.

Navigating the Complexities of Pain Management

This research highlights the importance of considering different delivery methods for analgesic drugs, exploring the trade-offs between sustained-release formulations and repeated injections. The study provides valuable insights into the efficacy and duration of action of buprenorphine, suggesting that sustained-release formulations may offer a more effective and less stressful approach to managing pain in animal models.

Sustained-Release Buprenorphine: A Promising Avenue for Pain Management

This research underscores the potential of sustained-release buprenorphine for managing pain in animal models. The study provides evidence suggesting that SB offers a longer duration of action and may minimize the need for repeated injections, potentially reducing stress and improving patient comfort.

Dr. Camel's Conclusion

Imagine a desert caravan traversing a challenging terrain. This research explores two approaches to managing pain, comparing a sustained-release formulation of buprenorphine to a standard protocol of repeated injections. The findings suggest that the sustained-release formulation may offer a smoother and more effective journey for those navigating the demanding landscape of pain management.
Date :
  1. Date Completed 2016-05-13
  2. Date Revised 2015-06-27
Further Info :

Pubmed ID

25488320

DOI: Digital Object Identifier

10.1177/0023677214562849

SNS
PICO Info
in preparation
Languages

English

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