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Administration of a probiotic with peanut oral immunotherapy: A randomized trial.

Author: BurksWesley, DonathSusan, LicciardiPaul, OrsiniFrancesca, PonsonbyAnne-Louise, RobinsonMarnie, SuEe Lyn, TangMimi L K, TeyDean

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that a combined therapy of probiotics and peanut oral immunotherapy (OIT) was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response. 82.1% of children receiving the combined therapy achieved sustained unresponsiveness compared to 3.6% of children receiving placebo. The combined therapy was associated with a greater number of adverse events, mostly with maintenance home dosing.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Coadministration of a bacterial adjuvant with oral immunotherapy (OIT) has been suggested as a potential treatment for food allergy. OBJECTIVE: To evaluate a combined therapy comprising a probiotic together with peanut OIT. METHODS: We performed a double-blind, placebo-controlled rando...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaci.2014.11.034

データ提供：米国国立医学図書館（NLM）

Probiotics and Peanut Oral Immunotherapy: A New Frontier in Food Allergy Treatment

Peanut allergy, like a hidden minefield in the desert of food sensitivities, can cause severe reactions and pose a significant risk to individuals with this condition. This study explores the potential of combining a probiotic with peanut oral immunotherapy (OIT), a treatment approach aimed at desensitizing individuals to peanut allergens.

The research team, like a group of scientists venturing into a new territory, investigated the impact of combining a probiotic with peanut OIT in children with peanut allergy. Their findings, like a well-mapped route through a treacherous terrain, revealed that this combined approach led to a significant improvement in tolerance to peanuts, indicating its potential as a promising treatment strategy.

Probiotics and Peanut Oral Immunotherapy: A Promising Path Towards Peanut Tolerance

This study, like a beacon in the desert, sheds light on a potentially transformative approach to peanut allergy management. The research suggests that combining probiotics with peanut OIT, like a skilled caravan leader navigating a challenging terrain, might offer a more effective and potentially longer-lasting path towards peanut tolerance.

A Journey Through the Desert of Peanut Allergy: New Hope for Food Allergy Sufferers

This study, like a refreshing spring in the desert, brings hope for individuals with peanut allergy. The research highlights the potential of this novel approach to desensitization, potentially offering a smoother and more comfortable journey through the desert of peanut allergy. It is essential to consult with a healthcare professional to determine the most appropriate treatment approach for your individual needs.

Dr. Camel's Conclusion

This study, like a desert explorer seeking to conquer the challenges of peanut allergy, investigates the potential of combining probiotics with peanut oral immunotherapy. The findings, like discovering a hidden oasis, suggest that this novel approach could offer a more effective and potentially longer-lasting path towards peanut tolerance, providing hope for individuals navigating the treacherous terrain of this food sensitivity.

Date :
  1. Date Completed 2015-04-30
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

25592987

DOI: Digital Object Identifier

10.1016/j.jaci.2014.11.034

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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