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Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial.

Author: ArdenNigel K, BatleyMichael, BirrellFraser, CocksKim, ConaghanPhilip G, DohertyMichael, EdwardsChris J, GarroodToby, GraingerAndrew J, GreenMichael, HewittCatherine, HughesRod, KingsburySarah R, MootsRobert, O'NeillTerence W, RoddyEdward, ScottDavid L, TharmanathanPuvan, TorgersonDavid J, WattFiona E

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Osteoarthritis (OA) is a major cause of disability with limited treatment options. OA pain is often linked to inflammation of the joint lining (synovitis). Methotrexate (MTX) is a safe and effective treatment for synovitis in other inflammatory joint diseases like rheumatoid arthritis. This study proposes that MTX could be a practical and safe treatment for reducing synovitis and pain in patients with knee OA.
Paper Details　
Original Abstract of the Article :
Osteoarthritis (OA) is the fastest growing cause of disability worldwide. Current treatments for OA are severely limited and a large proportion of people with OA live in constant, debilitating pain. There is therefore an urgent need for novel treatments to reduce pain. Synovitis is highly prevalent ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351849/

データ提供：米国国立医学図書館（NLM）

Methotrexate: A New Hope for Knee Osteoarthritis Pain

Osteoarthritis (OA), a common joint disease, is a major cause of disability worldwide. The current treatment options for OA are limited, and many individuals suffer from debilitating pain. This study investigates the potential of methotrexate (MTX), a drug often used for inflammatory arthritis, as a treatment for knee OA pain. The researchers believe that MTX could reduce synovitis, the inflammation of the joint lining, which is a major contributor to OA pain. This study's goal is to determine if MTX is a practical and safe way to reduce pain in knee OA.

Methotrexate: A Potential Solution for Knee OA Pain

This pragmatic phase III trial aims to evaluate the effectiveness of MTX for knee OA pain. The study will involve a randomized controlled trial, comparing MTX to standard treatments. If the results are positive, MTX could offer a new and effective treatment option for knee OA, potentially alleviating the suffering of millions of people.

The Importance of Addressing Knee OA Pain

Knee OA pain can significantly affect mobility and quality of life. This study offers hope for a new treatment that could address this debilitating condition. Just as a camel navigates the harsh desert terrain, people with knee OA need solutions to navigate their daily lives. This research holds the promise of making a real difference for those suffering from OA pain.

Dr. Camel's Conclusion

This study is a testament to the ongoing search for new and effective treatments for chronic pain. The researchers are exploring the potential of MTX, a drug previously used for inflammatory arthritis, to alleviate knee OA pain. This research demonstrates the tireless efforts of scientists to find solutions for common and debilitating conditions, mirroring the camel's tireless journey through the desert in search of sustenance and survival.

Date :
  1. Date Completed 2016-01-26
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

25872649

DOI: Digital Object Identifier

PMC4351849

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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