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Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn's disease: a systematic review and clinician surveys.

Author: GordonJason P, MaguireAndy, McEwanPhil C, PuellesJorge, SugrueDaniel M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

High treatment failure rates with existing biologics for ulcerative colitis (UC) and Crohn's disease (CD) indicate a need for new treatment options. These new treatments should be investigated in head-to-head randomized trials to compare their effectiveness and safety.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Comparative outcomes of patients with ulcerative colitis (UC) and Crohn's disease (CD) prescribed a biologic therapy are inconclusive. The aim of this research was to characterize the degree of unmet medical need in patients with UC or CD and to identify the potential role for new therap...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892747/

データ提供：米国国立医学図書館（NLM）

Unmet Needs in Ulcerative Colitis and Crohn's Disease: A Quest for Better Therapies

Ulcerative colitis and Crohn's disease, inflammatory bowel diseases that affect the digestive system, can be debilitating and challenging to manage. This research, like a caravan searching for a hidden oasis in a harsh desert, explores the limitations of current biologic therapies and highlights the need for new treatment options.

High Treatment Failure Rates: A Call for Innovation

The study reveals the high treatment failure rates associated with existing biologics, emphasizing the need for new therapies. It's like discovering a dried-up riverbed after a long journey, prompting us to seek out new sources of water.

New Biologic Treatments: A Promising Horizon

The authors call for head-to-head trials comparing existing and new biologics, advocating for a more comprehensive understanding of treatment effectiveness. This is like carefully surveying the desert landscape, seeking out the most promising paths to a successful outcome.

Dr. Camel's Conclusion

This study underscores the urgent need for improved treatments for ulcerative colitis and Crohn's disease. The high treatment failure rates associated with existing biologics necessitate a renewed focus on research and development of innovative therapies.

Date :
  1. Date Completed 2016-03-24
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

25933126

DOI: Digital Object Identifier

PMC4892747

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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