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Trial of short-course antimicrobial therapy for intraabdominal infection.

Author: , AskariReza, BantonKaysie L, CheadleWilliam G, ClaridgeJeffrey A, CocanourChristine S, CoimbraRaul, CookCharles H, DellingerE Patchen, DentDaniel L, DuaneTherese M, EvansHeather L, GuidryChristopher A, LipsettPamela A, LowryStephen F, MazuskiJohn E, MillerPreston R, NamiasNicholas, NapolitanoLena M, NathensAvery B, O'NeillPatrick J, PopovskyKimberley, RotsteinOri D, SawyerRobert G, WatsonChristopher M, WestMichaela A, WilsonMark A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

The outcomes of fixed-duration antibiotic therapy (approximately 4 days) were similar to those after a longer course of antibiotics (approximately 8 days) in patients with intraabdominal infections who had undergone an adequate source-control procedure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The successful treatment of intraabdominal infection requires a combination of anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy remains unclear. METHODS: We randomly assigned 518 patients with complicated intraabdominal infection and adequate ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25992746

データ提供：米国国立医学図書館（NLM）

Optimizing Antibiotic Therapy for Intraabdominal Infection

In the field of [surgery], optimizing antibiotic therapy for intraabdominal infections is a critical concern. This study investigates the optimal duration of antimicrobial therapy for complicated intraabdominal infection with adequate source control. Researchers conducted a [randomized controlled trial] involving 518 patients, comparing a short-course antibiotic therapy (4±1 calendar days) to a longer course that extended until the resolution of fever, leukocytosis, and ileus (maximum 10 days). The study found no significant difference in outcomes between the two groups, suggesting that a short-course antibiotic therapy may be as effective as a longer course in patients with adequate source control.

A Shorter Course for a Faster Recovery

The study's findings provide evidence for the effectiveness of a short-course antibiotic therapy for intraabdominal infection. The similar outcomes observed in the short-course group compared to the longer-course group suggest that a shorter duration of therapy may be sufficient in patients with adequate source control, potentially reducing the risk of antibiotic resistance and adverse effects.

Navigating the Desert of Infection

This study sheds light on the complexities of antibiotic therapy for intraabdominal infection. It's like finding a shortcut through the desert of infection, offering a potentially faster and safer path to recovery.

Dr.Camel's Conclusion

This study offers valuable insights into the management of intraabdominal infection. The findings provide evidence for the effectiveness of short-course antibiotic therapy in selected patients, potentially reducing the risk of antibiotic resistance and adverse effects.
Date :
  1. Date Completed 2015-06-05
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

25992746

DOI: Digital Object Identifier

NIHMS696862

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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