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Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance.

Author: LiuYan, QiuPing, WangGuiliang, WenJianbo, WenPing, XiaoXianzhong, XuLinfang, ZhouShu-Feng

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study compared the cost-effectiveness of three different drug combinations for treating chronic hepatitis B infection in patients who have developed resistance to adefovir dipivoxil. Lamivudine + adefovir dipivoxil was the most cost-effective option, with telbivudine + adefovir dipivoxil as an alternative in less developed areas and entecavir + adefovir dipivoxil in developed areas.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to analyze the cost-effectiveness of lamivudine (LMV), telbivudine (LdT), and entecavir (ETV) in treatment of chronic hepatitis B with adefovir dipivoxil (ADV) resistance. Two hundred and fifty-two patients were recruited and screened for resistance to ADV and randomly ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459610/

データ提供：米国国立医学図書館（NLM）

Finding the Right Path for Chronic Hepatitis B Treatment

Chronic hepatitis B, a persistent challenge for healthcare professionals, is like a desert that requires careful navigation. This study explores the cost-effectiveness of different treatment strategies, like mapping out various routes across a vast and complex landscape.

Cost-Effective Strategies for Hepatitis B Treatment

This study aimed to find the most effective and cost-efficient treatments for chronic hepatitis B, particularly in cases where the standard medication (adefovir dipivoxil) was no longer effective. The researchers compared three different treatment combinations, like comparing different paths across the desert, each with its own advantages and disadvantages. The study found that the combination of lamivudine and adefovir dipivoxil was the most cost-effective, while entecavir plus adefovir dipivoxil was the most expensive. This information can help guide healthcare providers in choosing the best treatment option for their patients.

Navigating the Desert of Hepatitis B Treatment

The study offers valuable insights into the treatment of chronic hepatitis B, providing a compass for healthcare professionals. It emphasizes the importance of considering both effectiveness and cost, like choosing the most efficient route through a resource-limited desert. This study underscores the need to tailor treatment strategies to individual patients and their specific circumstances.

Dr.Camel's Conclusion

This study provides a valuable roadmap for navigating the complex desert of chronic hepatitis B treatment. It emphasizes the importance of finding the most cost-effective and effective treatment, just as a camel navigates a challenging desert seeking the most reliable source of water.
Date :
  1. Date Completed 2016-02-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26082614

DOI: Digital Object Identifier

PMC4459610

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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