Morphine decreases ticagrelor concentrations but not its antiplatelet effects: a randomized trial in healthy volunteers.

Author: DerhaschnigUlla, HoblEva-Luise, JilmaBernd, KubicaJacek, ReiterBirgit, SchoergenhoferChristian, SchwameisMichael, StimpflThomas

Paper Details 
Original Abstract of the Article :
Our recent drug interaction trial with clopidogrel shows that morphine decreases the concentrations and pharmacodynamic effects of clopidogrel, which could lead to treatment failure in susceptible individuals. We hypothesized that the pharmacodynamic consequences of drug-drug interactions would be l...See full text at original site
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引用元:
https://doi.org/10.1111/eci.12550

データ提供:米国国立医学図書館(NLM)

Morphine and Ticagrelor: A Study on Drug Interactions

The use of medications often involves a delicate balancing act, considering potential interactions between drugs. This study investigates the potential interaction between morphine, a commonly used pain reliever, and ticagrelor, a medication used to prevent blood clots. The researchers conducted a randomized trial to examine the impact of morphine on ticagrelor concentrations and antiplatelet effects, aiming to assess the potential for drug-drug interactions.

Morphine's Impact on Ticagrelor: Unveiling the Complexity of Drug Interactions

The study reveals that morphine reduces ticagrelor concentrations but does not significantly affect its antiplatelet effects. This finding suggests that while morphine may influence ticagrelor levels, it does not necessarily compromise its intended therapeutic effect. However, the researchers caution that further research is needed to fully understand the potential implications of this interaction, particularly in patients with specific medical conditions or those receiving high doses of morphine.

Managing Medication Interactions: A Collaborative Approach

If you are taking ticagrelor or any other medications, it's crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements. Open communication and collaborative efforts between patients and healthcare providers are essential for managing potential drug interactions and ensuring the safe and effective use of medications.

Dr.Camel's Conclusion

This research, much like a camel navigating a complex desert ecosystem, explores the intricate world of drug interactions. The findings highlight the importance of considering potential interactions between medications, particularly in cases where drug concentrations may be affected. The researchers emphasize the need for careful monitoring and open communication between patients and healthcare providers to optimize medication safety and efficacy.

Date :
  1. Date Completed 2016-10-18
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26449338

DOI: Digital Object Identifier

10.1111/eci.12550

Related Literature

SNS
PICO Info
in preparation
Languages

English

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