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Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles.

Author: FujiokaK, HompeschM, KrentzA J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review explores the history of anti-obesity pharmacotherapy and the challenges of developing safe and effective weight loss medications. It discusses how the withdrawal of several drugs due to serious side effects has influenced the regulatory landscape for new anti-obesity drugs.
Paper Details　
Original Abstract of the Article :
Pharmacotherapy directed toward reducing body weight may provide benefits for both curbing obesity and lowering the risk of obesity-associated comorbidities; however, many weight loss medications have been withdrawn from the market because of serious adverse effects. Examples include pulmonary hyper...See full text at original site
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引用元：
https://doi.org/10.1111/dom.12657

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Obesity Treatment: Navigating the Side Effects of Pharmacotherapy

Obesity is a growing global health concern, and pharmacotherapy plays a significant role in weight management. However, the history of obesity medications is marked by challenges, with some drugs withdrawn due to serious side effects. This review chronicles the evolution of pharmacological obesity treatments, focusing on the adverse side effects associated with various medications.

A Desert of Challenges: Navigating the Side Effects of Obesity Medications

The development of effective and safe obesity medications is a challenging endeavor. This review provides a comprehensive overview of the historical evolution of obesity pharmacotherapy, highlighting the lessons learned from past experiences with medications that had serious adverse effects.

A New Dawn in the Desert: Emerging Approaches to Obesity Treatment

Despite the challenges, ongoing research and development offer hope for new and safer obesity medications. The authors highlight the importance of rigorous safety testing and post-marketing surveillance to ensure the long-term safety and efficacy of new weight-loss drugs.

Dr. Camel's Conclusion

Navigating the desert of obesity treatment requires a cautious approach. This review offers a valuable historical perspective on the challenges and successes of pharmacotherapy, emphasizing the importance of balancing potential benefits and risks.
Date :
  1. Date Completed 2017-10-31
  2. Date Revised 2017-11-28
Further Info :

Pubmed ID

26936802

DOI: Digital Object Identifier

10.1111/dom.12657

SNS
PICO Info
in preparation
Languages

English

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