A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers.

Author: GroboschThomas, HiraokaKotaro, InamiAkie, KomamuraHiroshi, MatsudaRin, MaurerMarcus, MiyakeMasayasu, TakedaKazuko, TashiroManabu, YamadaYusuke, YanaiKazuhiko

Paper Details 
Original Abstract of the Article :
Antihistamines are often used for treating allergic rhinitis. However, many older antihistamines cause sedative side effects. The sedative effects of antihistamines on car-driving have been investigated. This has not been investigated for levocetirizine, a new-generation antihistamine, in Asian popu...See full text at original site
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引用元:
https://doi.org/10.1002/hup.2524

データ提供:米国国立医学図書館(NLM)

Antihistamines and Driving: A Camel's Journey Through the Sands of Alertness

Antihistamines are commonly used to alleviate allergic rhinitis symptoms, but some older medications can cause sedation and impair driving ability. This study investigates the [effects of levocetirizine, fexofenadine, and diphenhydramine] on driving performance in healthy Japanese volunteers using a [simulated car-driving study]. The researchers found that [levocetirizine had a minimal impact on driving performance], while [fexofenadine and diphenhydramine caused significant impairments] in driving skills, particularly in tasks requiring alertness and reaction time.

A Desert of Drowsiness: Navigating the Sands of Driving Performance

Imagine a camel traversing a desert under a scorching sun, the heat causing drowsiness and impairing its ability to navigate safely. This analogy reflects the potential impact of certain antihistamines on driving performance. The study's findings suggest that while levocetirizine might offer a smoother journey, fexofenadine and diphenhydramine could lead to a more precarious path, potentially affecting alertness and reaction time.

A Camel's Advice: Stay Hydrated and Aware

As a camel, I know the importance of staying hydrated and alert in the desert. If you're taking antihistamines, it's crucial to be aware of their potential effects on driving performance. If you experience drowsiness or reduced alertness, it's best to avoid driving or seek alternative transportation. Remember, safety is paramount, and a little bit of camel wisdom can help you navigate the sands of driving safely.

Dr. Camel's Conclusion

This study underscores the importance of understanding the potential impact of antihistamines on driving ability. While levocetirizine may be a safer choice for those who need to drive, fexofenadine and diphenhydramine can significantly impair driving performance. Remember, navigating the desert of driving requires alertness and awareness, and choosing the right antihistamine can help ensure a safe journey.

Date :
  1. Date Completed 2017-12-15
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26999510

DOI: Digital Object Identifier

10.1002/hup.2524

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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