Liquid liothyronine to obtain target TSH in differentiated thyroid cancer patients.

Author: CentanniMarco, TrimboliPierpaolo, ViriliCamilla

Paper Details 
Original Abstract of the Article :
In the last ten years a liquid formulation of liothyronine (L-T3) became available. To date, no studies on its systematic use have been reported. This study is aimed at assessing the reliability of liquid L-T3 in achieving target TSH in patients with differentiated thyroid cancers (DTC). Twenty-one ...See full text at original site
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引用元:
https://doi.org/10.1507/endocrj.EJ16-0040

データ提供:米国国立医学図書館(NLM)

Liquid Liothyronine: A New Hope for Differentiated Thyroid Cancer Patients?

The field of differentiated thyroid cancer (DTC) is constantly evolving, and the quest for effective treatments continues. This research delves into the use of liquid liothyronine (L-T3) in DTC patients. The researchers aimed to assess the efficacy of liquid L-T3 in achieving target thyroid-stimulating hormone (TSH) suppression, a crucial element in managing DTC. The study included 21 high-risk DTC patients whose TSH levels remained elevated despite high doses of levothyroxine (L-T4). The researchers found that combining L-T4 with liquid L-T3, starting with a fixed dose of 3.55 μg, resulted in the attainment of target TSH in all patients. They noted that the required L-T3 dose was significantly correlated with body weight, suggesting a personalized approach might be necessary. Furthermore, no significant adverse events were reported, indicating the potential safety of liquid L-T3.

Liquid Liothyronine Offers Tailored Treatment for DTC Patients

This research highlights the potential benefits of liquid L-T3 in achieving optimal TSH suppression in high-risk DTC patients who haven't responded well to L-T4 alone. The study suggests that liquid L-T3 provides a more individualized treatment option for DTC patients, allowing for precise dosage adjustments to achieve desired results. The researchers observed that the required L-T3 dose was significantly correlated with body weight, suggesting that personalized treatment approaches may be crucial for optimal outcomes.

A New Frontier in Thyroid Cancer Treatment

The findings of this study suggest that liquid L-T3 could be a valuable addition to the treatment armamentarium for DTC patients. The personalized approach offered by liquid L-T3, with its minimal side effects, could lead to improved outcomes and enhanced quality of life for patients. However, further research is needed to confirm these findings and explore long-term efficacy and safety.

Dr.Camel's Conclusion

Imagine a vast desert, where the only source of life-giving water is a single oasis. Similarly, in the world of thyroid cancer treatment, liquid L-T3 may offer a new oasis, providing a tailored and effective solution for those struggling with persistent TSH levels. This research provides a promising beacon of hope for patients, allowing them to navigate the complex landscape of thyroid cancer treatment with increased confidence and better outcomes. But, like all oases, further exploration is needed to fully understand its potential and ensure its long-term sustainability.

Date :
  1. Date Completed 2017-03-03
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

27000530

DOI: Digital Object Identifier

10.1507/endocrj.EJ16-0040

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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