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Effects of omeprazole and aluminum hydroxide/magnesium hydroxide on riociguat absorption.

Author: Artmeier-BrandtUlrike, BeckerCorina, FreyReiner, MückWolfgang, UngerSigrun, WeimannGerrit

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Riociguat is a drug used to treat pulmonary hypertension. This study investigated the impact of coadministration of omeprazole or AlOH/MgOH on riociguat pharmacokinetics. Omeprazole and AlOH/MgOH reduced riociguat bioavailability, indicating that antacids should not be taken within an hour of receiving riociguat. No dose adjustment is needed for proton pump inhibitors.
Paper Details　
Original Abstract of the Article :
Riociguat, a soluble guanylate cyclase stimulator, is a novel therapy for the treatment of pulmonary hypertension. Riociguat bioavailability is reduced in neutral versus acidic conditions and therefore may be affected by concomitant use of medications that increase gastric pH. The effect of coadmini...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860530/

データ提供：米国国立医学図書館（NLM）

Riociguat Absorption: A Camel's Guide to Drug Interactions in the Desert of Pharmacology

Riociguat, a drug used for the treatment of pulmonary hypertension, relies on a delicate balance of factors to work effectively. This research explores the potential impact of omeprazole and aluminum hydroxide/magnesium hydroxide (AlOH/MgOH) on riociguat absorption. The study aims to understand how these commonly used medications might affect the bioavailability of riociguat.

Navigating the Desert of Drug Interactions: Avoiding Unexpected Pitfalls

The study found that both omeprazole and AlOH/MgOH, medications that increase gastric pH, significantly reduced riociguat bioavailability. This is like encountering unexpected sandstorms in the desert, which can disrupt a caravan's journey. Understanding these drug interactions is crucial for ensuring effective treatment and minimizing potential adverse effects.

A Safe and Effective Journey: Understanding Drug Interactions

This research underscores the importance of considering potential drug interactions. It's like having a reliable guidebook for navigating the desert of medications, avoiding unexpected obstacles and ensuring a smooth and successful journey. By being aware of potential interactions, healthcare providers can optimize treatment plans and ensure the safety and effectiveness of medications for their patients.

Dr.Camel's Conclusion

This study highlights the importance of considering drug interactions, particularly for medications like riociguat that are sensitive to gastric pH. Understanding these interactions is crucial for ensuring effective treatment and minimizing potential adverse effects. As we continue to explore the vast desert of pharmacology, we can learn from these findings and create a safer and more effective medication landscape for our patients.

Date :
  1. Date Completed 2016-05-10
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

27162626

DOI: Digital Object Identifier

PMC4860530

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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