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Evaluation of the Lipid Concentrations after Switching from Antiretroviral Drug Tenofovir Disoproxil Fumarate/Emtricitabine to Abacavir Sulfate/Lamivudine in Virologically-suppressed Human Immunodeficiency Virus-infected Patients.

Author: AraeHirotaka, FujitaJiro, KamiKaoru, MaedaSaori, MiyagiKyoko, MoromiMakiko, NakamuraHideta, NakamuraKatsunori, TasatoDaisuke, TateyamaMasao, UeharaHitoshi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This retrospective study examined the change in lipid levels after switching from tenofovir disoproxil fumatate/emtricitabine (TDF/FTC) to abacavir/lamivudine (ABC/3TC) in virologically suppressed HIV-infected patients. The study found that switching resulted in significant increases in LDL, HDL, and total cholesterol levels, suggesting a potential lipid-related side effect of switching therapies.
Paper Details　
Original Abstract of the Article :
Objective Recently, tenofovir disoproxil fumatate (TDF)-related side effects, such as renal nephrotoxicity and reduction of bone mineral density, have been reported. Consequently, increased switching from fixed-dose tablet TDF and emtricitabine (TDF/FTC) to abacavir and lamivudine (ABC/3TC) has occu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216139/

データ提供：米国国立医学図書館（NLM）

Evaluation of Lipid Concentrations after Switching from Antiretroviral Drug Tenofovir Disoproxil Fumarate/Emtricitabine to Abacavir Sulfate/Lamivudine

The development of effective antiretroviral therapies has revolutionized the treatment of HIV infection, significantly improving the lives of millions of people. This study examines the impact of switching from one antiretroviral regimen to another, focusing on the potential effects on lipid levels. This research, like a skilled navigator charting a new course through a vast ocean, explores the uncharted territories of antiretroviral therapy.

Switching Regimens: A Potential for Lipid Elevation

This study, like a ship encountering a hidden reef, reveals a potential complication associated with switching from tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) to abacavir (ABC)/lamivudine (3TC). The study found that switching regimens led to significant increases in low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) levels. This finding highlights the importance of monitoring lipid levels in patients undergoing antiretroviral regimen changes.

Health Implications and Applications

This study, like a warning sign in the desert, underscores the need for careful monitoring of lipid levels in patients undergoing antiretroviral regimen changes. Clinicians should be aware of the potential for lipid elevation associated with switching from TDF/FTC to ABC/3TC and implement appropriate monitoring and management strategies to minimize cardiovascular risks.

Dr. Camel's Conclusion

This study, like a compass guiding a traveler through the desert, provides valuable insights into the potential lipid-related side effects associated with switching antiretroviral regimens. Careful monitoring and management are crucial to ensure the long-term health and well-being of patients receiving antiretroviral therapy.

Date :
  1. Date Completed 2017-02-06
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27904105

DOI: Digital Object Identifier

PMC5216139

SNS
PICO Info
in preparation
Languages

English

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