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Human diploid cell rabies vaccine purified by zonal centrifugation: a controlled study of antibody response and side effects following primary and booster pre-exposure immunizations.

Author: DreesenD W, FishbeinD B, HolmesD F, LeyA B, PacerR E, Reid-SandenF L, SanderlinD W, SumnerJ W, TongT C, YagerP A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

A purified human diploid cell rabies vaccine (HDCV) was found to be preferable to conventional HDCV for booster vaccination. It was equally immunogenic but caused fewer adverse reactions.
Paper Details　
Original Abstract of the Article :
Systemic allergic reactions following booster immunizations have complicated rabies pre-exposure prophylaxis with the human diploid cell rabies vaccine licensed in the US (conventional HDCV). We conducted two studies comparing an HDCV purified by zonal centrifugation to conventional HDCV. In a study...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(89)90159-x

データ提供：米国国立医学図書館（NLM）

Human Diploid Cell Rabies Vaccine: A Controlled Study of Antibody Response and Side Effects

Rabies, a deadly viral disease transmitted through the saliva of infected animals, is a significant public health concern. This study compares the antibody response and side effects of two human diploid cell rabies vaccines: a conventional vaccine and a purified vaccine. Researchers conducted two controlled studies involving volunteers receiving primary pre-exposure immunization and booster immunizations.

Purified Rabies Vaccine: A Safer Option for Booster Immunizations

The study revealed that both conventional and purified rabies vaccines elicited a robust immune response, providing protection against rabies. However, the purified vaccine was associated with fewer side effects, particularly during booster immunizations. The study found a significantly lower incidence of moderate or severe reactions in individuals receiving the purified vaccine compared to those receiving the conventional vaccine.

A Safe Passage Through the Desert of Rabies: A Purified Vaccine

Imagine a desert with dangerous animals lurking in the shadows. A purified rabies vaccine, like a protective shield, can provide a safer passage through this treacherous landscape, offering protection from the deadly virus without the burden of significant side effects.

Dr. Camel's Conclusion

This study provides compelling evidence for the superiority of the purified human diploid cell rabies vaccine over the conventional vaccine for booster immunizations. The study highlights the importance of considering both efficacy and safety when selecting a rabies vaccine, particularly for booster doses, to ensure optimal protection and minimize the risk of adverse reactions.

Date :
  1. Date Completed 1989-12-08
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

2815979

DOI: Digital Object Identifier

10.1016/0264-410x(89)90159-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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