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Efficacy, Side Effects, and Monitoring of Oral Cyclosporine in Interstitial Cystitis-Bladder Pain Syndrome.

Author: CrescenzeIryna M, LiJianbo, MooreCourtenay, ShoskesDaniel A, TuckyBarbara

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral cyclosporine A (CyA) can be effective in a proportion of patients with refractory interstitial cystitis-bladder pain syndrome (IC-BPS). Patients with Hunner lesions are more likely to benefit. Monitoring drug levels can minimize toxicity.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy of oral cyclosporine A (CyA) in the treatment of refractory interstitial cystitis-bladder pain syndrome (IC-BPS) and to assess safety using drug level and renal function monitoring. MATERIALS AND METHODS: Patients with IC-BPS who failed at least 2 prior treatment...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28528859

データ提供：米国国立医学図書館（NLM）

Cyclosporine for Interstitial Cystitis-Bladder Pain Syndrome: A New Therapeutic Approach

Interstitial cystitis-bladder pain syndrome (IC-BPS), a chronic condition characterized by bladder pain and discomfort, can significantly impact quality of life. This study investigates the efficacy of oral cyclosporine A (CyA), an immunosuppressant drug, in the treatment of refractory IC-BPS, meaning cases that haven't responded to conventional therapies. The researchers conducted an open-label study, monitoring patients' symptoms and drug levels over a three-month period. The findings suggest that CyA may be an effective treatment option for some patients with refractory IC-BPS, particularly those with Hunner lesions, a specific type of bladder inflammation.

Cyclosporine: A Potential Treatment for Refractory IC-BPS

This research offers hope for patients with refractory IC-BPS, suggesting that oral cyclosporine A (CyA) may be an effective treatment option. The study found that CyA led to improvement in symptoms for a portion of patients, particularly those with Hunner lesions, a specific type of bladder inflammation. This research suggests that CyA could be a valuable addition to the treatment arsenal for IC-BPS.

Navigating the Desert of Bladder Pain

Just as a camel must find ways to navigate a challenging desert landscape, patients with IC-BPS need effective strategies to manage their condition. This research offers a potential new avenue for treatment, exploring the use of cyclosporine A (CyA) for refractory IC-BPS. It's like finding a hidden oasis in the desert – this research could lead to a more effective and targeted approach to managing this chronic and often debilitating condition.

Dr.Camel's Conclusion

This research underscores the need for ongoing research and development of new therapies for IC-BPS. It's like a camel searching for a hidden oasis in a vast and challenging desert. The findings suggest that cyclosporine A (CyA) could be a potential treatment option for some patients, providing a glimmer of hope for those struggling with this chronic and often debilitating condition.

Date :
  1. Date Completed 2018-11-27
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

28528859

DOI: Digital Object Identifier

NIHMS878091

SNS
PICO Info
in preparation
Languages

English

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