Management of flu-like syndrome with cetirizine in patients with relapsing-remitting multiple sclerosis during therapy with interferon beta: Results of a randomized, cross-over, placebo-controlled pilot study.

Author: AlbaneseMaria, BoffaLaura, ButtariFabio, CentonzeDiego, LandiDoriana, MonteleoneFabrizia, MottaCaterina, PumaElisa, RossiSilvia

Paper Details 
Original Abstract of the Article :
Flu-like syndrome (FLS) is a common adverse event experienced by patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon beta (IFNβ). FLS can lead to poor treatment adherence and early IFNβ discontinuation. The involvement of interleukin-6 (IL-6) in the occurrence of FLS ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501388/

データ提供:米国国立医学図書館(NLM)

Cetirizine for Flu-Like Syndrome in Multiple Sclerosis Patients

The [flu-like syndrome (FLS)] experienced by patients with [relapsing-remitting multiple sclerosis (RRMS)] during [interferon beta (IFNβ)] treatment can be a real obstacle. It can lead to [poor treatment adherence] and even [early discontinuation] of IFNβ. This study investigated whether [cetirizine], a [second-generation histamine H1 receptor antagonist], could help alleviate FLS. The researchers hypothesized that cetirizine, known for its ability to reduce [interleukin-6 (IL-6)], might be a key to easing FLS.

Cetirizine Shows Potential for Alleviating Flu-Like Symptoms

This study explored whether [cetirizine] could be a helpful tool for managing [flu-like syndrome] in patients with [multiple sclerosis] who are receiving [interferon beta] treatment. The findings suggest that cetirizine may have a positive effect on reducing FLS, potentially by reducing [IL-6] levels. However, this was a small pilot study, and further research is needed to confirm these findings and determine the optimal dosage and long-term effects of cetirizine in this context.

Navigating the Challenges of Multiple Sclerosis

Living with [multiple sclerosis] can present unique challenges, and [flu-like syndrome] is a common side effect of certain treatments. This study offers a glimpse into a potential solution for managing FLS, highlighting the importance of exploring different approaches to improve patient well-being. It's crucial to work closely with your doctor to develop a personalized treatment plan that addresses your individual needs and minimizes side effects.

Dr.Camel's Conclusion

This study serves as a reminder that [multiple sclerosis] is a complex condition requiring a multi-faceted approach to management. While more research is needed to fully understand the role of [cetirizine] in treating FLS, this study offers hope for a potential solution to a common side effect of IFNβ therapy. It underscores the importance of continued research and innovation in finding better ways to manage this chronic condition.

Date :
  1. Date Completed 2017-10-04
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28686675

DOI: Digital Object Identifier

PMC5501388

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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