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Efficacy and safety of inhaled corticosteroids relative to fluticasone propionate: a systematic review of randomized controlled trials in asthma.

Author: AggarwalBhumika, Daley-YatesPeter, MulgirigamaAruni, ShantakumarSumitra, YeoSee-Hwee

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Inhaled fluticasone propionate (FP) was found to be as effective or more effective than other inhaled corticosteroids (ICS) in treating asthma. FP was comparable to beclomethasone dipropionate (BDP) and budesonide (BUD) in terms of efficacy and safety. Although there were no significant differences between FP and ciclesonide (CIC) in terms of efficacy, CIC had a smaller impact on cortisol levels.
Paper Details　
Original Abstract of the Article :
Many trials have been published comparing inhaled corticosteroid (ICS) treatments in asthma. However, mixed results necessitate the summarization of available evidence to aid in decision-making. Areas covered: This systematic review evaluated randomized controlled trials (RCTs) that compared the eff...See full text at original site
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引用元：
https://doi.org/10.1080/17476348.2017.1361824

データ提供：米国国立医学図書館（NLM）

Inhaled Corticosteroids: A Comparative Study

The field of [respiratory medicine] is constantly seeking ways to improve the management of [asthma]. This study provides a comprehensive overview of the [efficacy and safety] of various [inhaled corticosteroids] used for treating [asthma]. The authors conducted a [systematic review] of [randomized controlled trials] comparing [fluticasone propionate] to other [inhaled corticosteroids], including [beclomethasone dipropionate, budesonide, and ciclesonide]. Their analysis revealed [a wealth of information on the relative benefits and risks of different inhaled corticosteroids]. A key finding is that [fluticasone propionate appears to be a strong contender in terms of efficacy and safety].

Understanding the Nuances of Inhaled Corticosteroids

The research provides valuable insights into the [pharmacodynamic and pharmacokinetic properties] of different [inhaled corticosteroids]. The authors discovered that [fluticasone propionate's higher potency and low oral bioavailability] may contribute to its favorable outcomes. Interestingly, [ciclesonide] demonstrated a [smaller impact on cortisol levels] compared to [fluticasone propionate]. This difference is attributed to [ciclesonide's incomplete conversion to active metabolite].

Making Informed Choices for Asthma Management

This study offers valuable information for both [clinicians and patients] seeking to manage [asthma]. By understanding the [efficacy and safety profiles] of different [inhaled corticosteroids], patients can work with their healthcare providers to make informed decisions about the most appropriate treatment options. This knowledge empowers individuals to actively participate in their own healthcare, promoting optimal management of [asthma] and improving quality of life.

Dr.Camel's Conclusion

Just like a camel navigates the desert landscape, navigating the world of asthma treatments requires careful consideration. This study provides a compass for clinicians and patients, helping them choose the right inhaled corticosteroid for effective and safe asthma management. The findings highlight the importance of understanding the nuances of different treatments to optimize outcomes and improve the quality of life for individuals with asthma.

Date :
  1. Date Completed 2018-04-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28752776

DOI: Digital Object Identifier

10.1080/17476348.2017.1361824

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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