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A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.

Author: HoxhaMalvina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Rheumatoid arthritis is a condition where the body's immune system attacks the joints, causing inflammation, pain, and damage. While steroids and NSAIDs can reduce pain and inflammation, they don't stop the damage to cartilage and bone. Treatment options include disease-modifying medications, steroids, NSAIDs, and biological agents.
Paper Details　
Original Abstract of the Article :
Rheumatoid arthritis is characterized by the production of eicosanoids, cytokines, adhesion molecules, infiltration of T and B lymphocytes in the synovium and oxygen reduction accompanied by the cartilage degradation. Eicosanoids are responsible for the progressive destruction of cartilage and bone,...See full text at original site
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引用元：
https://doi.org/10.1016/j.advms.2017.06.004

データ提供：米国国立医学図書館（NLM）

Eicosanoid Pathways in Rheumatoid Arthritis: A Complex and Challenging Landscape

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and pain in the joints. It's like a relentless desert storm that can erode and damage the joints, making movement difficult and painful. This study delves into the role of eicosanoids, lipid signaling molecules, in the development and progression of RA.

The authors discuss the complex interplay of eicosanoids, cytokines, and immune cells in RA, highlighting their involvement in joint inflammation and cartilage degradation. They emphasize that current treatments, including steroids, NSAIDs, and biological agents, primarily focus on symptom management and do not effectively stop the underlying disease process.

New Therapeutic Targets: A Promise for a More Effective Treatment

This study underscores the need for further research to develop novel therapeutic strategies that target the underlying mechanisms of RA. By focusing on eicosanoid pathways, researchers may be able to develop drugs that more effectively control inflammation and prevent joint damage. This is like seeking a new and reliable source of water in the desert, offering hope for a more sustainable and effective solution.

Dr. Camel's Conclusion

This study is like a journey through the harsh desert landscape of rheumatoid arthritis, revealing the complex interplay of eicosanoids and immune cells in the disease process. It highlights the need for innovative approaches to target these pathways and develop more effective treatments for this debilitating condition. Finding new therapeutic targets for RA is like discovering a hidden oasis in the desert, offering a potential cure for this devastating disease.

Date :
  1. Date Completed 2018-09-17
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28818745

DOI: Digital Object Identifier

10.1016/j.advms.2017.06.004

SNS
PICO Info
in preparation
Languages

English

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