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Tenofovir alafenamide as a rescue therapy in a patient with HBV-cirrhosis with a history of Fanconi syndrome and multidrug resistance.
Author: BorghiMarta, FacchettiFloriana, GaggarAnuj, GalmozziEnrico, GrossiGlenda, LamperticoPietro, LoglioAlessandro, LunghiGiovanna, SoffrediniRoberta
Original Abstract of the Article :
Tenofovir disoproxil fumarate (TDF) is a recommended first-line therapy for both naïve and experienced patients with chronic hepatitis B (CHB), although reduced estimated glomerular filtration rate (eGFR), hypophosphatemia, hyperphosphaturia and Fanconi syndrome have been reported in some patients. ...See full text at original site
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.jhep.2017.08.020
データ提供:米国国立医学図書館(NLM)
Tenofovir Alafenamide: A Rescue Therapy for HBV-Cirrhosis
Chronic hepatitis B (CHB) is a serious liver infection that requires long-term treatment. This case report describes a patient with HBV-cirrhosis who developed multidrug resistance and Fanconi syndrome. The authors demonstrate the successful use of tenofovir alafenamide (TAF) as a rescue therapy in this challenging case.
TAF: A Lifeline in the Desert of HBV-Cirrhosis
This case study showcases the potential of TAF as a rescue therapy for patients with HBV-cirrhosis who have developed resistance to other antiviral medications. TAF, a newer version of tenofovir with a better safety profile, effectively suppressed viral replication without worsening the patient's renal function. It's like finding a hidden well in the arid landscape of HBV-cirrhosis, providing a much-needed source of hydration and hope for this patient.
Navigating the Complexities of HBV Treatment: A Journey of Resilience
This case report highlights the importance of individualized treatment approaches in managing CHB. It underscores the need for clinicians to remain vigilant, monitoring patients closely and adjusting treatment plans as needed. It's like navigating a complex and ever-changing desert, requiring adaptability, resilience, and a deep understanding of the terrain to ensure the best possible outcomes for patients.
Dr.Camel's Conclusion
TAF offers a promising new option for treating CHB, particularly in patients who have developed resistance to other antiviral therapies. This case report serves as a valuable example of the potential for innovative treatments to overcome complex medical challenges. It's a testament to the ongoing quest for effective and safe therapies, offering hope for a healthier future for those affected by this chronic liver infection.
Date :
- Date Completed n.d.
- Date Revised 2019-11-20
Further Info :
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English
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