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Preliminary pharmacokinetics of intravenous and subcutaneous dolasetron and pharmacodynamics of subcutaneous dolasetron in healthy cats.

Author: CaressAmber L, DavisLeigh, GustafsonDanial L, HansenRyan J, HerndonAndrea K, LigasSabina, QuimbyJessica M, SiebergLiberty G, WittenburgLuke A

Clinical Trial, VeterinaryClinical trials involving animals. They are conducted to evaluate the safety and efficacy of new drugs and treatments and contribute to the advancement of veterinary medicine.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dolasetron is a drug that is used to prevent nausea and vomiting. This study looked at the effects of giving dolasetron to cats. The study found that dolasetron did not prevent vomiting in cats, and more research is needed to determine if a higher dose would be effective.
Paper Details　
Original Abstract of the Article :
Objectives The objectives were to evaluate the pharmacokinetics (PK) of subcutaneous (SC) and intravenous (IV) dolasetron and the pharmacodynamics (PD) of SC dolasetron in healthy cats. Methods Five cats with unremarkable complete blood count, serum biochemistry and urinalyses were utilized. In the ...See full text at original site
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引用元：
https://doi.org/10.1177/1098612X17729310

データ提供：米国国立医学図書館（NLM）

Investigating the Effectiveness of Dolasetron for Preventing Vomiting in Cats

As a veterinarian, I often face the challenge of managing nausea and vomiting in cats. It's not always easy to find the right medication that effectively controls these symptoms without causing unwanted side effects. This study examines the pharmacokinetics (PK) and pharmacodynamics (PD) of dolasetron, a drug used to prevent nausea and vomiting, in cats. It's like carefully studying the map of the drug's journey through the body and its effects on the cat's system.

Dolasetron's Effectiveness in Cats

The researchers found that dolasetron is quickly metabolized into an active metabolite, hydrodolasetron, and that the drug was not effective in preventing vomiting induced by xylazine, a common anesthetic. This means that we need to find alternative ways to manage nausea and vomiting in cats, especially when using xylazine. It's like discovering that a compass doesn't point in the right direction in certain parts of the desert. We need to explore other routes to reach our destination.

Navigating the Challenges of Nausea and Vomiting in Cats

This research highlights the need for further investigation into the appropriate dosing and administration of dolasetron in cats. It's a reminder that we need to be careful and thoughtful when choosing medications for our feline companions. We need to find the right tools for the job, just like a camel needs the right equipment to traverse the harsh desert landscape.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding the specific needs and responses of different species when developing medications. While dolasetron might be effective for humans, its effectiveness in cats needs further evaluation. It's a reminder that each species is unique, and we need to carefully consider their individual needs and responses to ensure safe and effective treatment.

Date :
  1. Date Completed 2019-09-09
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

28905667

DOI: Digital Object Identifier

10.1177/1098612X17729310

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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