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Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial): study protocol for a randomised controlled trial.

Author: , GallowayJames, GeorgopoulouSofia, IbrahimFowzia, LemppHeidi, MartinNaomi H, ProtheroLouise, ScottDavid L, SturtJackie, TomBrian, ToshJonathan, WailooAllan

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.

Overview

Untreated rheumatoid arthritis (RA) can worsen over time, causing disability and impacting quality of life. While aggressive treatment has been shown to be effective in early and established cases, there are no standard guidelines for people with RA who have moderate disease activity. This study aims to determine if intensive treatment for these patients leads to more remissions after 12 months. The study will also examine the impact on disability, quality of life, and the cost-effectiveness of this approach.
Paper Details　
Original Abstract of the Article :
Uncontrolled active rheumatoid arthritis can lead to increasing disability and reduced quality of life over time. 'Treating to target' has been shown to be effective in active established disease and also in early disease. However, there is a lack of nationally agreed treatment protocols for patient...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723045/

データ提供：米国国立医学図書館（NLM）

Intensive Management for Intermediate Rheumatoid Arthritis: Is It Worth the Effort?

Rheumatoid arthritis (RA) is a chronic condition that can significantly impact quality of life, making it feel like navigating a desert of pain and stiffness. This study investigates the effectiveness of intensive management in achieving remission in patients with intermediate RA. It's like exploring different strategies for traversing a challenging desert landscape, seeking the best approach for overcoming obstacles.

The study is designed to compare the outcomes of intensive management with standard care in patients with intermediate RA. This is like comparing different routes through the desert – some may be faster or more comfortable, while others may offer more scenic views. The study aims to determine whether intensive management, like taking a more rigorous and demanding path, leads to greater remission rates, ultimately improving patient outcomes.

Intensive Management for RA: A Potential Path to Remission

This study explores a potentially impactful approach to managing RA. The findings could provide valuable insights into the effectiveness of intensive management strategies and help guide future treatment decisions. It's like discovering a new path through the desert, one that might lead to a brighter future for those living with RA.

Intensive Management for RA: A Potential Path to Remission

This study explores a potentially impactful approach to managing RA. The findings could provide valuable insights into the effectiveness of intensive management strategies and help guide future treatment decisions. It's like discovering a new path through the desert, one that might lead to a brighter future for those living with RA.

Dr.Camel's Conclusion

This study is a reminder that the desert of RA can be challenging to navigate. The search for effective treatments continues, and this study offers a promising avenue for exploration. It's like searching for a hidden oasis, a place of respite and healing in the midst of a challenging journey. By exploring new approaches and evaluating their effectiveness, we can continue to improve the lives of those living with RA and help them find a path to a better future.

Date :
  1. Date Completed 2018-07-31
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

29221496

DOI: Digital Object Identifier

PMC5723045

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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