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Population pharmacokinetics and pharmacodynamics of ticagrelor and AR-C124910XX in Chinese healthy male subjects.

Author: LiuShuaibing, ShiXiangfen, SunZhiyong, TianXin, XueLing, ZhangXiaojian, ZhuZhenfeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ticagrelor, a new antiplatelet drug, works more quickly and consistently than clopidogrel, providing faster onset and offset of antiplatelet effects.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Ticagrelor, the first reversible P2Y<sub>12</sub> receptor antagonist, exhibits faster onset and offset of antiplatelet effects and more consistent platelet inhibition than clopidogrel in both healthy subjects and patients with stable coronary artery disea...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-018-2427-3

データ提供：米国国立医学図書館（NLM）

A Closer Look at Ticagrelor: Population Pharmacokinetics and Pharmacodynamics

In the world of cardiovascular health, preventing blood clots is like navigating a treacherous desert, where a single misstep could lead to serious consequences. Ticagrelor, a new generation antiplatelet medication, has emerged as a promising solution for preventing blood clots, particularly in patients with coronary artery disease. This research investigates the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite, AR-C124910XX, in a population of healthy Chinese male subjects. The study aimed to understand how these drugs are processed and how effectively they inhibit platelet aggregation in this specific population.

Ticagrelor: A Potent Tool for Preventing Blood Clots

The study found that ticagrelor and its active metabolite, AR-C124910XX, exhibited consistent and effective platelet inhibition in healthy Chinese male subjects. This finding suggests that ticagrelor could be a safe and effective antiplatelet medication for this population, potentially offering protection against cardiovascular events. Further research is needed to confirm its effectiveness in patients with coronary artery disease and other cardiovascular conditions.

Navigating the Desert of Blood Clots: Maintaining Heart Health

Maintaining heart health is essential for a long and fulfilling life. This includes adopting a healthy lifestyle that includes regular exercise, a balanced diet, and managing stress. It's also important to be aware of your family history and any potential risk factors for cardiovascular disease. Consult with your doctor to understand your individual risk profile and discuss appropriate preventive measures.

Dr.Camel's Conclusion

This research provides valuable insights into the pharmacokinetics and pharmacodynamics of ticagrelor, a promising antiplatelet medication. The study's findings suggest that ticagrelor could be an effective tool for preventing blood clots in healthy Chinese male subjects. Remember, navigating the desert of cardiovascular health requires a proactive approach, combining healthy lifestyle choices with appropriate medical interventions.
Date :
  1. Date Completed 2018-10-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

29442148

DOI: Digital Object Identifier

10.1007/s00228-018-2427-3

Related Literature

Article Analysis
・Effects of clopidogrel・Effects of ticagrelor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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