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Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density.

Author: BradburnM, EastellR, GossielF, McCloskeyE V, NaylorK E, PaggiosiM A, PeelN F A, WalshJ S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study looked at the effects of stopping different types of bisphosphonate medications (ibandronate, alendronate, risedronate) used to treat osteoporosis in postmenopausal women. After stopping treatment, all groups experienced an increase in bone turnover markers (BTMs), indicating increased bone breakdown, and a decrease in bone mineral density (BMD) in the hip, although levels did not return to their original levels before treatment.
Paper Details　
Original Abstract of the Article :
The antiresorptive potency varies between different bisphosphonates. We investigated the effect of stopping oral bisphosphonate treatment for postmenopausal osteoporosis (ibandronate, alendronate, risedronate) on BTMs and BMD. After stopping treatment, all three groups showed an increase in BTMs and...See full text at original site
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引用元：
https://doi.org/10.1007/s00198-018-4460-6

データ提供：米国国立医学図書館（NLM）

Bone Turnover: Investigating the Effects of Discontinuing Bisphosphonates

The field of bone health is like a complex desert ecosystem, where bone turnover plays a crucial role in maintaining its strength. This study investigates the effect of discontinuing bisphosphonates, a class of medications used to treat osteoporosis, on bone turnover markers and bone density. The researchers, like careful observers of the desert, tracked changes in bone markers after stopping bisphosphonate treatment.

Discontinuation Leads to Bone Turnover

Their observations, much like the shifting sands in a desert, revealed an increase in bone turnover markers. This suggests that the body's natural bone remodeling process resumes after bisphosphonate treatment ends. While the study found a decrease in hip bone density, none of the groups returned to pre-treatment levels, indicating a potential need for ongoing management to maintain bone health.

Navigating Bone Health

The findings highlight the importance of careful monitoring and potential need for ongoing management after stopping bisphosphonate treatment. It's like being a traveler in the desert, constantly adjusting your path to ensure optimal hydration and avoid exhaustion.

Dr.Camel's Conclusion

This research provides valuable insights into the impact of discontinuing bisphosphonates on bone health. Understanding these effects is like having a compass to guide us in navigating the desert of bone turnover.

Date :
  1. Date Completed 2019-10-23
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29525970

DOI: Digital Object Identifier

10.1007/s00198-018-4460-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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